Clinical Significance of Circulating MiRNA Detection in Lung Cancer

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2016 Apr 2

PMID 27034265

Citations 15

Authors

Chen Zhao

Funian Lu

Hongxia Chen

Fuqiang Zhao

Ziwen Zhu

Xianda Zhao

Honglei Chen

Affiliations

Soon will be listed here.

Abstract

Lung cancer is the most common cancer in the world and the leading cause of tumor death among males. MicroRNAs (miRNAs) are single-stranded RNAs of approximately 22 nucleotides and constituted a new class of gene regulators in humans. As a novel class of emerging biomarkers, the aberrant expression of miRNA has been detected in various tumors. miRNAs are secreted into circulation by microvesicles from the broken tumor cells and act as either oncogenes or tumor suppressors in tumor tissues. In this review, we summarized different circulating miRNAs and their expression level as well as predictable values in lung cancer patients which were investigated in recent 5 years. Circulating miRNAs are found to be dysregulated and have association with clinicopathological parameters and overall survival in lung cancer patients. In conclusion, circulating miRNAs have the potential for distinguishing lung cancer patients from healthy individuals, with the advantages of stabilities, noninvasiveness and cost-effectiveness.

Citing Articles

LncRNA MIR100HG affects the proliferation and metastasis of lung cancer cells through mediating the microRNA-5590-3p/DCBLD2 axis.

Min S, Zhang L, Zhang L, Liu F, Liu M Immun Inflamm Dis. 2024; 12(4):e1223.

PMID: 38602284 PMC: 11007817. DOI: 10.1002/iid3.1223.

Exosomal RNAs in diagnosis and therapies.

Narang P, Shah M, Beljanski V Noncoding RNA Res. 2022; 7(1):7-15.

PMID: 35087990 PMC: 8777382. DOI: 10.1016/j.ncrna.2022.01.001.

Chidamide and Radiotherapy Synergistically Induce Cell Apoptosis and Suppress Tumor Growth and Cancer Stemness by Regulating the MiR-375-EIF4G3 Axis in Lung Squamous Cell Carcinomas.

Huang X, Bi N, Wang J, Ren H, Pan D, Lu X J Oncol. 2021; 2021:4936207.

PMID: 34194495 PMC: 8214506. DOI: 10.1155/2021/4936207.

Serum MiR-4687-3p Has Potential for Diagnosis and Carcinogenesis in Non-small Cell Lung Cancer.

Liu M, Si Q, Ouyang S, Zhou Z, Wang M, Zhao C Front Genet. 2020; 11:597508.

PMID: 33329742 PMC: 7721467. DOI: 10.3389/fgene.2020.597508.

Circulating MiR-10b, MiR-1 and MiR-30a Expression Profiles in Lung Cancer: Possible Correlation with Clinico-pathologic Characteristics and Lung Cancer Detection.

Sheervalilou R, Lotfi H, Shirvaliloo M, Sharifi A, Nazemiyeh M, Zarghami N Int J Mol Cell Med. 2020; 8(2):118-129.

PMID: 32215263 PMC: 7081081. DOI: 10.22088/IJMCM.BUMS.8.2.118.

References

Aushev V, Zborovskaya I, Laktionov K, Girard N, Cros M, Herceg Z . Comparisons of microRNA patterns in plasma before and after tumor removal reveal new biomarkers of lung squamous cell carcinoma. PLoS One. 2013; 8(10):e78649. PMC: 3793941. DOI: 10.1371/journal.pone.0078649. View

Vickers K, Palmisano B, Shoucri B, Shamburek R, Remaley A . MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011; 13(4):423-33. PMC: 3074610. DOI: 10.1038/ncb2210. View

Yan H, Ma J, Wang L, Gu W . Expression and significance of circulating microRNA-31 in lung cancer patients. Med Sci Monit. 2015; 21:722-6. PMC: 4362487. DOI: 10.12659/MSM.893213. View

Heegaard N, Schetter A, Welsh J, Yoneda M, Bowman E, Harris C . Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int J Cancer. 2011; 130(6):1378-86. PMC: 3259258. DOI: 10.1002/ijc.26153. View

Ulivi P, Zoli W . miRNAs as non-invasive biomarkers for lung cancer diagnosis. Molecules. 2014; 19(6):8220-37. PMC: 6271142. DOI: 10.3390/molecules19068220. View

Mar-Aguilar F, Mendoza-Ramirez J, Malagon-Santiago I, Espino-Silva P, Santuario-Facio S, Ruiz-Flores P . Serum circulating microRNA profiling for identification of potential breast cancer biomarkers. Dis Markers. 2013; 34(3):163-9. PMC: 3810231. DOI: 10.3233/DMA-120957. View

Zhao Q, Cao J, Wu Y, Liu X, Han J, Huang X . Circulating miRNAs is a potential marker for gefitinib sensitivity and correlation with EGFR mutational status in human lung cancers. Am J Cancer Res. 2015; 5(5):1692-705. PMC: 4497436. View

Ng E, Li R, Shin V, Jin H, Leung C, Ma E . Circulating microRNAs as specific biomarkers for breast cancer detection. PLoS One. 2013; 8(1):e53141. PMC: 3536802. DOI: 10.1371/journal.pone.0053141. View

Roth C, Kasimir-Bauer S, Pantel K, Schwarzenbach H . Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol. 2011; 5(3):281-91. PMC: 5528292. DOI: 10.1016/j.molonc.2011.02.002. View

10.

Kawaguchi T, Komatsu S, Ichikawa D, Morimura R, Tsujiura M, Konishi H . Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer. Br J Cancer. 2013; 108(2):361-9. PMC: 3566805. DOI: 10.1038/bjc.2012.546. View

11.

Huang Y, Yu J . Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis: An update and review. World J Gastroenterol. 2015; 21(34):9863-86. PMC: 4566381. DOI: 10.3748/wjg.v21.i34.9863. View

12.

Wang R, Zheng Y, Wang P, Zhang J . Serum miR-125a-5p, miR-145 and miR-146a as diagnostic biomarkers in non-small cell lung cancer. Int J Clin Exp Pathol. 2015; 8(1):765-71. PMC: 4348919. View

13.

Zheng D, Haddadin S, Wang Y, Gu L, Perry M, Freter C . Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol. 2011; 4(6):575-86. PMC: 3160609. View

14.

Markou A, Sourvinou I, Vorkas P, Yousef G, Lianidou E . Clinical evaluation of microRNA expression profiling in non small cell lung cancer. Lung Cancer. 2013; 81(3):388-396. DOI: 10.1016/j.lungcan.2013.05.007. View

15.

Rani S, Gately K, Crown J, OByrne K, ODriscoll L . Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma. Cancer Biol Ther. 2013; 14(12):1104-12. PMC: 3912033. DOI: 10.4161/cbt.26370. View

16.

Yuxia M, Zhennan T, Wei Z . Circulating miR-125b is a novel biomarker for screening non-small-cell lung cancer and predicts poor prognosis. J Cancer Res Clin Oncol. 2012; 138(12):2045-50. DOI: 10.1007/s00432-012-1285-0. View

17.

Huang J, Wu J, Li Y, Li X, Yang T, Yang Q . Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer. Biomed Res Int. 2014; 2014:364316. PMC: 4217347. DOI: 10.1155/2014/364316. View

18.

Wei J, Gao W, Zhu C, Liu Y, Mei Z, Cheng T . Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. Chin J Cancer. 2011; 30(6):407-14. PMC: 4013415. DOI: 10.5732/cjc.010.10522. View

19.

Dou H, Wang Y, Su G, Zhao S . Decreased plasma let-7c and miR-152 as noninvasive biomarker for non-small-cell lung cancer. Int J Clin Exp Med. 2015; 8(6):9291-8. PMC: 4538081. View

20.

Zhu W, Luo B, An J, He J, Chen D, Xu L . Differential expression of miR-125a-5p and let-7e predicts the progression and prognosis of non-small cell lung cancer. Cancer Invest. 2014; 32(8):394-401. DOI: 10.3109/07357907.2014.922569. View