Regulation of Microglial Survival and Proliferation in Health and Diseases

Overview

Journal Semin Immunol

Specialty Allergy & Immunology

Date 2016 Apr 2

PMID 27033414

Citations 27

Authors

Tyler K Ulland

Yaming Wang

Marco Colonna

Affiliations

Soon will be listed here.

Abstract

Microglia play an important role in the development and maintenance of the central nervous system (CNS) under homeostatic conditions as well as during neurodegenerative diseases. Recent observations in human genomics and advances in genetic mouse models have provided insights into signaling pathways that control development, survival, proliferation and function of microglia. Alteration of these pathways contributes to the pathogenesis of CNS diseases. Here we review the current literature regarding the roles of these microglial pathways in both the normal and diseased brain and discuss areas that require further investigation.

Citing Articles

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond.

Afzal A, Afzal Z, Bizink S, Davis A, Makahleh S, Mohamed Y Curr Issues Mol Biol. 2024; 46(8):7795-7811.

PMID: 39194679 PMC: 11352848. DOI: 10.3390/cimb46080462.

Microglial CD11b Knockout Contributes to Axonal Debris Clearance and Axonal Degradation Attenuation via IGF-1 After Acute Optic Nerve Injury.

Zhou J, Lin S, Hu Q, Li X, Chen X, Luo L Invest Ophthalmol Vis Sci. 2023; 64(5):7.

PMID: 37145604 PMC: 10168008. DOI: 10.1167/iovs.64.5.7.

Facial nerve injury-associated hippocampal microglial activation.

Ceron J, Troncoso J Biomedica. 2022; 42(1):109-206.

PMID: 35471181 PMC: 9048578. DOI: 10.7705/biomedica.6216.

Discovery of a novel SHIP1 agonist that promotes degradation of lipid-laden phagocytic cargo by microglia.

Pedicone C, Fernandes S, Matera A, Meyer S, Loh S, Ha J iScience. 2022; 25(4):104170.

PMID: 35465359 PMC: 9020084. DOI: 10.1016/j.isci.2022.104170.

Disease-associated microglial activation prevents photoreceptor degeneration by suppressing the accumulation of cell debris and neutrophils in degenerating rat retinas.

He J, Fu Y, Ge L, Dai J, Fang Y, Li Y Theranostics. 2022; 12(6):2687-2706.

PMID: 35401812 PMC: 8965480. DOI: 10.7150/thno.67954.

References

Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J . Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011; 43(5):436-41. PMC: 3090745. DOI: 10.1038/ng.801. View

Yeung Y, Wang Y, Einstein D, Lee P, Stanley E . Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages. J Biol Chem. 1998; 273(27):17128-37. DOI: 10.1074/jbc.273.27.17128. View

Wegiel J, Wisniewski H, Dziewiatkowski J, Tarnawski M, Kozielski R, Trenkner E . Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res. 1998; 804(1):135-9. DOI: 10.1016/s0006-8993(98)00618-0. View

Lill C, Rengmark A, Pihlstrom L, Fogh I, Shatunov A, Sleiman P . The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement. 2015; 11(12):1407-1416. PMC: 4627856. DOI: 10.1016/j.jalz.2014.12.009. View

Nandi S, Gokhan S, Dai X, Wei S, Enikolopov G, Lin H . The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Dev Biol. 2012; 367(2):100-13. PMC: 3388946. DOI: 10.1016/j.ydbio.2012.03.026. View

Thakkar J, Dolecek T, Horbinski C, Ostrom Q, Lightner D, Barnholtz-Sloan J . Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 2014; 23(10):1985-96. PMC: 4185005. DOI: 10.1158/1055-9965.EPI-14-0275. View

Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M . Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population. J Alzheimers Dis. 2014; 41(4):1031-8. DOI: 10.3233/JAD-140225. View

Bailey C, DeVaux L, Farzan M . The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E. J Biol Chem. 2015; 290(43):26033-42. PMC: 4646256. DOI: 10.1074/jbc.M115.677286. View

Rosenthal S, Bamne M, Wang X, Berman S, Snitz B, Klunk W . More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk. Neurobiol Aging. 2015; 36(8):2443.e21-6. PMC: 4465085. DOI: 10.1016/j.neurobiolaging.2015.04.012. View

10.

Waisman A, Ginhoux F, Greter M, Bruttger J . Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems. Trends Immunol. 2015; 36(10):625-636. DOI: 10.1016/j.it.2015.08.005. View

11.

Parkhurst C, Yang G, Ninan I, Savas J, Yates 3rd J, Lafaille J . Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013; 155(7):1596-609. PMC: 4033691. DOI: 10.1016/j.cell.2013.11.030. View

12.

Kiialainen A, Hovanes K, Paloneva J, Kopra O, Peltonen L . Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS. Neurobiol Dis. 2005; 18(2):314-22. DOI: 10.1016/j.nbd.2004.09.007. View

13.

Komohara Y, Ohnishi K, Kuratsu J, Takeya M . Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. J Pathol. 2008; 216(1):15-24. DOI: 10.1002/path.2370. View

14.

Stanley E, Chitu V . CSF-1 receptor signaling in myeloid cells. Cold Spring Harb Perspect Biol. 2014; 6(6). PMC: 4031967. DOI: 10.1101/cshperspect.a021857. View

15.

Jiao B, Liu X, Tang B, Hou L, Zhou L, Zhang F . Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China. Neurobiol Aging. 2014; 35(10):2422.e9-2422.e11. DOI: 10.1016/j.neurobiolaging.2014.04.025. View

16.

Tos M, Trojaborg N, Thomsen J . The contralateral ear after translabyrinthine removal of acoustic neuromas: is there a drill-noise generated hearing loss?. J Laryngol Otol. 1989; 103(9):845-9. DOI: 10.1017/s0022215100110278. View

17.

Yu J, Jiang T, Wang Y, Wang H, Zhang W, Hu N . Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals. Neurobiol Aging. 2013; 35(4):937.e1-3. DOI: 10.1016/j.neurobiolaging.2013.10.075. View

18.

Paolicelli R, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P . Synaptic pruning by microglia is necessary for normal brain development. Science. 2011; 333(6048):1456-8. DOI: 10.1126/science.1202529. View

19.

Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, Cuyvers E . TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014; 6(243):243ra86. DOI: 10.1126/scitranslmed.3009093. View

20.

Coniglio S, Eugenin E, Dobrenis K, Stanley E, West B, Symons M . Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol Med. 2012; 18:519-27. PMC: 3356419. DOI: 10.2119/molmed.2011.00217. View