Natural Killer Cells Regulate Th1/Treg and Th17/Treg Balance in Chlamydial Lung Infection

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2016 Mar 31

PMID 27028780

Citations 27

Authors

Jing Li

Xiaojing Dong

Lei Zhao

Xiao Wang

Yan Wang

Xi Yang

Hong Wang

Weiming Zhao

Affiliations

Soon will be listed here.

Abstract

Natural killer (NK) cell is an important component in innate immunity, playing a critical role in bridging innate and adaptive immunity by modulating the function of other immune cells including T cells. In this study, we focused on the role of NK cells in regulating Th1/Treg and Th17/Treg balance during chlamydial lung infection. We found that NK cell-depleted mice showed decreased Th1 and Th17 cells, which was correlated with reduced interferon-γ, interleukin (IL)-12, IL-17 and IL-22 production as well as T-bet and receptor-related orphan receptor gamma t expression compared with mice treated with the isotype control antibody. In contrast, NK cell depletion significantly increased Treg in cell number and related transcription factor (Foxp3) expression. The opposite trends of changes of Th1/Th17 and Treg led to significant reduction in the Th1/Treg and Th17/Treg ratios. The data implicate that NK cells play an important role in host defence against chlamydial lung infection, mainly through maintaining Th1/Treg and Th17/Treg balance.

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