Inherited Thrombophilia and Reproductive Disorders

Overview

Journal J Turk Ger Gynecol Assoc

Publisher Galenos Publishing House

Specialty Gynecology & Obstetrics

Date 2016 Mar 31

PMID 27026779

Citations 4

Authors

Spyros A Liatsikos

Panagiotis Tsikouras

Bachar Manav

Roland Csorba

Georg Friedrich von Tempelhoff

Georgios Galazios

Affiliations

Soon will be listed here.

Abstract

Apart from its established role in the pathogenesis of venous thromboembolism (VTE), inherited thrombophilia has been proposed as a possible cause of pregnancy loss and vascular gestational complications. There is a lot of controversy in the literature on the relationship between inherited prothrombotic defects and these obstetric complications. This is a review of the literature on inherited thrombophilia and reproductive disorders. Factor V Leiden, prothrombin G20210A mutation, and protein S deficiency seem to be associated with late and recurrent early pregnancy loss, while their impact on other pregnancy complications is conflicting. No definite association has been established between protein C and antithrombin deficiency and adverse pregnancy outcome, primarily due to their low prevalence. Screening is suggested only for women with early recurrent loss or late pregnancy loss. Anticoagulant treatment during pregnancy should be considered for women with complications who were tested positive for thrombophilia.

Citing Articles

Research trends and hotspots of recurrent pregnancy loss with thrombophilia: a bibliometric analysis.

Deng Y, Liu S, Zhao M, Zhao F, Guo J, Huang Y BMC Pregnancy Childbirth. 2022; 22(1):944.

PMID: 36526982 PMC: 9756660. DOI: 10.1186/s12884-022-05210-z.

[Clinical manifestations and gene analysis of 18 cases of hereditary protein S deficiency].

Zhang D, Xue F, Fu R, Chen Y, Liu X, Liu W Zhonghua Xue Ye Xue Za Zhi. 2022; 43(1):48-53.

PMID: 35231993 PMC: 8980663. DOI: 10.3760/cma.j.issn.0253-2727.2022.01.010.

Combined presence of coagulation factor XIII V34L and plasminogen activator inhibitor 1 4G/5G gene polymorphisms significantly contribute to recurrent pregnancy loss in Serbian population.

Joksic I, Mikovic Z, Filimonovic D, Munjas J, Karadzov O, Egic A J Med Biochem. 2020; 39(2):199-207.

PMID: 33033453 PMC: 7526018. DOI: 10.2478/jomb-2019-0028.

The obstetric complications in women with hereditary thrombophilia.

Mitriuc D, Popusoi O, Catrinici R, Friptu V Med Pharm Rep. 2019; 92(2):106-110.

PMID: 31086835 PMC: 6510366. DOI: 10.15386/cjmed-1097.

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