Multiple Layers of Stress-Induced Regulation in TRNA Biology

Overview

Journal Life (Basel)

Specialty Biology

Date 2016 Mar 30

PMID 27023616

Citations 34

Authors

Hsiao-Yun Huang

Anita K Hopper

Affiliations

Soon will be listed here.

Abstract

tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating apoptosis and several other biological processes. There are multiple layers of regulatory mechanisms in each step of tRNA biogenesis. For example, tRNA 3' trailer processing is altered upon nutrient stress; tRNA modification is reprogrammed under various stresses; nuclear accumulation of tRNAs occurs upon nutrient deprivation; tRNA halves accumulate upon oxidative stress. Here we address how environmental stresses can affect nearly every step of tRNA biology and we describe the possible regulatory mechanisms that influence the function or expression of tRNAs under stress conditions.

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