Ranolazine Improves Autonomic Balance in Heart Failure when Added to Guideline-driven Therapy

Overview

Journal Heart Int

Date 2016 Mar 23

PMID 27004100

Citations 3

Authors

Gary L Murray

Joseph Colombo

Affiliations

Soon will be listed here.

Abstract

Background: The effect of ranolazine (RAN) on cardiac autonomic balance in congestive heart failure (CHF) was studied.

Methods: Fifty-four CHF patients were randomized to (1) open-label RAN (RANCHF) added to usual therapy vs. (2) usual therapy (NORANCHF). Parasympathetic and sympathetic (P&S) measurements were taken at baseline and at 12 months.

Results: A total of 16/27 (59%) patients in both groups had initially abnormal P&S measures, including high sympathovagal balance (SB), cardiovascular autonomic neuropathy (CAN) or both. High SB normalized in 10/12 (83%) RANCHF patients vs. 2/11 (18%) NORANCHF patients. SB became high in 5/11 (45%) NORANCHF vs. 1/11 (9%) RANCHF patients. CAN improved in 4/6 (67%) RANCHF patients vs. 5/7 (45%) NORANCHF patients. CAN developed in 1/11 (9%) RANCHF vs. 4/11 (36%) NORANCHF patients. Since improved P&S in RANCHF patients seemed independent of improved brain natriuretic peptide and impedance cardiography (BioZ) measurements, 5 day RAN was given to 30 subjects without CHF but with high SB or CAN. P&S improved in 90% of these subjects.

Conclusions: RAN improves unfavorable P&S activity in CHF possibly by a direct effect upon autonomic sodium channels.

Citing Articles

Ranolazine: An Old Drug with Emerging Potential; Lessons from Pre-Clinical and Clinical Investigations for Possible Repositioning.

Rouhana S, Virsolvy A, Fares N, Richard S, Thireau J Pharmaceuticals (Basel). 2022; 15(1).

PMID: 35056088 PMC: 8777683. DOI: 10.3390/ph15010031.

Metabolic Therapy in Heart Failure.

Lopatin Y Card Fail Rev. 2017; 1(2):112-117.

PMID: 28785443 PMC: 5490953. DOI: 10.15420/cfr.2015.1.2.112.

Ranolazine Therapy Reduces Non-ST-Segment-Elevation Myocardial Infarction and Unstable Angina in Coronary Disease Patients with Angina.

Murray G, Colombo J Int J Angiol. 2016; 25(3):159-64.

PMID: 27574382 PMC: 5001871. DOI: 10.1055/s-0036-1572364.

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