Neural Basis of Reward Anticipation and Its Genetic Determinants

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2016 Mar 23

PMID 27001827

Citations 24

Authors

Tianye Jia

Christine Macare

Sylvane Desrivieres

Dante A Gonzalez

Chenyang Tao

Xiaoxi Ji

Barbara Ruggeri

Frauke Nees

Tobias Banaschewski

Gareth J Barker

Arun L W Bokde

Uli Bromberg

Christian Buchel

Patricia J Conrod

Rachel Dove

Vincent Frouin

Jurgen Gallinat

Hugh Garavan

Penny A Gowland

Andreas Heinz

Bernd Ittermann

Mark Lathrop

Herve Lemaitre

Jean-Luc Martinot

Tomas Paus

Zdenka Pausova

Jean-Baptiste Poline

Marcella Rietschel

Trevor Robbins

Michael N Smolka

Christian P Muller

Jianfeng Feng

Adrian Rothenfluh

Herta Flor

Gunter Schumann

Affiliations

Soon will be listed here.

Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

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