Management of Liver Failure: From Transplantation to Cell-Based Therapy

Overview

Journal Cell Med

Publisher Sage Publications

Date 2016 Mar 22

PMID 26998399

Citations 2

Authors

Maria Giovanna Francipane

Melchiorre Cervello

Giovanni Battista Vizzini

Giada Pietrosi

Giuseppe Montalto

Affiliations

Soon will be listed here.

Abstract

The severe shortage of deceased donor organs has driven a search for alternative methods of treating liver failure. In this context, cell-based regenerative medicine is emerging as a promising interdisciplinary field of tissue repair and restoration, able to contribute to improving health in a minimally invasive fashion. Several cell types have allowed long-term survival in experimental models of liver injury, but their therapeutic potential in humans should be regarded with deep caution, because few clinical trials are currently available and the number of patients enrolled so far is too small to assess benefits versus risks. This review summarizes the current literature on the physiological role of endogenous stem cells in liver regeneration and on the therapeutic benefits of exogenous stem cell administration with specific emphasis on the potential clinical uses of mesenchymal stem cells. Moreover, critical points that still need clarification, such as the exact identity of the stem-like cell population exerting the beneficial effects, as well as the limitations of stem cell-based therapies, are discussed.

Citing Articles

Generation of Hepatobiliary Cell Lineages from Human Induced Pluripotent Stem Cells: Applications in Disease Modeling and Drug Screening.

Pasqua M, Di Gesu R, Chinnici C, Conaldi P, Francipane M Int J Mol Sci. 2021; 22(15).

PMID: 34360991 PMC: 8348238. DOI: 10.3390/ijms22158227.

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo.

Rashidi H, Luu N, Alwahsh S, Ginai M, Alhaque S, Dong H Arch Toxicol. 2018; 92(10):3117-3129.

PMID: 30155720 PMC: 6132688. DOI: 10.1007/s00204-018-2280-2.

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