The Promising Alliance of Anti-cancer Electrochemotherapy with Immunotherapy

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2016 Mar 20

PMID 26993326

Citations 38

Authors

Christophe Y Calvet

Lluis M Mir

Affiliations

Soon will be listed here.

Abstract

Anti-tumor electrochemotherapy, which consists in increasing anti-cancer drug uptake by means of electroporation, is now implanted in about 140 cancer treatment centers in Europe. Its use is supported by the English National Institute for Health and Care Excellence for the palliative treatment of skin metastases, and about 13,000 cancer patients were treated by this technology by the end of 2015. Efforts are now focused on turning this local anti-tumor treatment into a systemic one. Electrogenetherapy, that is the electroporation-mediated transfer of therapeutic genes, is currently under clinical evaluation and has brought excitement to enlarge the anti-cancer armamentarium. Among the promising electrogenetherapy strategies, DNA vaccination and cytokine-based immunotherapy aim at stimulating anti-tumor immunity. We review here the interests and state of development of both electrochemotherapy and electrogenetherapy. We then emphasize the potent beneficial outcome of the combination of electrochemotherapy with immunotherapy, such as immune checkpoint inhibitors or strategies based on electrogenetherapy, to simultaneously achieve excellent local debulking anti-tumor responses and systemic anti-metastatic effects.

Citing Articles

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References

Kishida T, Asada H, Satoh E, Tanaka S, Shinya M, Hirai H . In vivo electroporation-mediated transfer of interleukin-12 and interleukin-18 genes induces significant antitumor effects against melanoma in mice. Gene Ther. 2001; 8(16):1234-40. DOI: 10.1038/sj.gt.3301519. View

Caraco C, Mozzillo N, Marone U, Simeone E, Benedetto L, Di Monta G . Long-lasting response to electrochemotherapy in melanoma patients with cutaneous metastasis. BMC Cancer. 2013; 13:564. PMC: 4219480. DOI: 10.1186/1471-2407-13-564. View

Melero I, Berman D, Aznar M, Korman A, Perez Gracia J, Haanen J . Evolving synergistic combinations of targeted immunotherapies to combat cancer. Nat Rev Cancer. 2015; 15(8):457-72. DOI: 10.1038/nrc3973. View

Cemazar M, Sersa G, Miklavcic D . Electrochemotherapy with cisplatin in the treatment of tumor cells resistant to cisplatin. Anticancer Res. 1999; 18(6A):4463-6. View

Brizio M, Fava P, Astrua C, Cavaliere G, Savoia P . Complete regression of melanoma skin metastases after electrochemotherapy plus ipilimumab treatment: an unusual clinical presentation. Eur J Dermatol. 2015; 25(3):271-2. DOI: 10.1684/ejd.2015.2522. View

Mir L, Banoun H, Paoletti C . Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp Cell Res. 1988; 175(1):15-25. DOI: 10.1016/0014-4827(88)90251-0. View

Gerlini G, Sestini S, Di Gennaro P, Urso C, Pimpinelli N, Borgognoni L . Dendritic cells recruitment in melanoma metastasis treated by electrochemotherapy. Clin Exp Metastasis. 2012; 30(1):37-45. DOI: 10.1007/s10585-012-9505-1. View

Daud A, DeConti R, Andrews S, Urbas P, Riker A, Sondak V . Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol. 2008; 26(36):5896-903. PMC: 2645111. DOI: 10.1200/JCO.2007.15.6794. View

Mir L, Belehradek M, Domenge C, Orlowski S, Poddevin B, BELEHRADEK Jr J . [Electrochemotherapy, a new antitumor treatment: first clinical trial]. C R Acad Sci III. 1991; 313(13):613-8. View

10.

Mozzillo N, Simeone E, Benedetto L, Curvietto M, Giannarelli D, Gentilcore G . Assessing a novel immuno-oncology-based combination therapy: Ipilimumab plus electrochemotherapy. Oncoimmunology. 2015; 4(6):e1008842. PMC: 4485758. DOI: 10.1080/2162402X.2015.1008842. View

11.

Breton M, Mir L . Microsecond and nanosecond electric pulses in cancer treatments. Bioelectromagnetics. 2011; 33(2):106-23. DOI: 10.1002/bem.20692. View

12.

Ledur P, Villodre E, Paulus R, Cruz L, Flores D, Lenz G . Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells. Purinergic Signal. 2011; 8(1):39-48. PMC: 3286536. DOI: 10.1007/s11302-011-9252-9. View

13.

Cutrera J, King G, Jones P, Kicenuik K, Gumpel E, Xia X . Safe and effective treatment of spontaneous neoplasms with interleukin 12 electro-chemo-gene therapy. J Cell Mol Med. 2015; 19(3):664-75. PMC: 4369822. DOI: 10.1111/jcmm.12382. View

14.

Cemazar M, Todorovic V, Scancar J, Lampreht U, Stimac M, Kamensek U . Adjuvant TNF-α therapy to electrochemotherapy with intravenous cisplatin in murine sarcoma exerts synergistic antitumor effectiveness. Radiol Oncol. 2015; 49(1):32-40. PMC: 4362604. DOI: 10.1515/raon-2015-0005. View

15.

Villemejane J, Mir L . Physical methods of nucleic acid transfer: general concepts and applications. Br J Pharmacol. 2009; 157(2):207-19. PMC: 2697808. DOI: 10.1111/j.1476-5381.2009.00032.x. View

16.

Lohr F, Lo D, Zaharoff D, Hu K, Zhang X, Li Y . Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Res. 2001; 61(8):3281-4. View

17.

Quaglino P, Mortera C, Osella-Abate S, Barberis M, Illengo M, Rissone M . Electrochemotherapy with intravenous bleomycin in the local treatment of skin melanoma metastases. Ann Surg Oncol. 2008; 15(8):2215-22. DOI: 10.1245/s10434-008-9976-0. View

18.

Andre F, Gehl J, Sersa G, Preat V, Hojman P, Eriksen J . Efficiency of high- and low-voltage pulse combinations for gene electrotransfer in muscle, liver, tumor, and skin. Hum Gene Ther. 2009; 19(11):1261-71. DOI: 10.1089/hum.2008.060. View

19.

Roux S, Bernat C, Al-Sakere B, Ghiringhelli F, Opolon P, Carpentier A . Tumor destruction using electrochemotherapy followed by CpG oligodeoxynucleotide injection induces distant tumor responses. Cancer Immunol Immunother. 2008; 57(9):1291-300. PMC: 11031045. DOI: 10.1007/s00262-008-0462-0. View

20.

Belehradek M, Domenge C, Luboinski B, Orlowski S, BELEHRADEK Jr J, Mir L . Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer. 1993; 72(12):3694-700. DOI: 10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co;2-2. View