Collagen-binding Proteins of Streptococcus Mutans and Related Streptococci

Overview

Journal Mol Oral Microbiol

Specialties Dentistry
Microbiology

Date 2016 Mar 19

PMID 26991416

Citations 30

Authors

A Aviles-Reyes

J H Miller

J A Lemos

J Abranches

Affiliations

Soon will be listed here.

Abstract

The ability of Streptococcus mutans to interact with collagen through the expression of collagen-binding proteins (CBPs) bestows this oral pathogen with an alternative to the sucrose-dependent mechanism of colonization classically attributed to caries development. Based on the abundance and distribution of collagen throughout the human body, stringent adherence to this molecule grants S. mutans with the opportunity to establish infection at different host sites. Surface proteins, such as SpaP, WapA, Cnm and Cbm, have been shown to bind collagen in vitro, and it has been suggested that these molecules play a role in colonization of oral and extra-oral tissues. However, robust collagen binding is not achieved by all strains of S. mutans, particularly those that lack Cnm or Cbm. These observations merit careful dissection of the contribution from these different CBPs towards tissue colonization and virulence. In this review, we will discuss the current understanding of mechanisms used by S. mutans and related streptococci to colonize collagenous tissues, and the possible contribution of CBPs to infections in different sites of the host.

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References

Petersen F, Assev S, van der Mei H, Busscher H, Scheie A . Functional variation of the antigen I/II surface protein in Streptococcus mutans and Streptococcus intermedius. Infect Immun. 2001; 70(1):249-56. PMC: 127646. DOI: 10.1128/IAI.70.1.249-256.2002. View

Russell R . Wall-associated protein antigens of Streptococcus mutans. J Gen Microbiol. 1979; 114(1):109-15. DOI: 10.1099/00221287-114-1-109. View

Szymanski C, Wren B . Protein glycosylation in bacterial mucosal pathogens. Nat Rev Microbiol. 2005; 3(3):225-37. DOI: 10.1038/nrmicro1100. View

Dinkla K, Talay S, Morgelin M, Graham R, Rohde M, Nitsche-Schmitz D . Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever. PLoS One. 2009; 4(3):e4666. PMC: 2646144. DOI: 10.1371/journal.pone.0004666. View

Yurchenco P . Basement membranes: cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol. 2011; 3(2). PMC: 3039528. DOI: 10.1101/cshperspect.a004911. View

Mansur A, Dal Bo C, Fukushima J, Issa V, Grinberg M, Pomerantzeff P . Relapses, recurrences, valve replacements, and mortality during the long-term follow-up after infective endocarditis. Am Heart J. 2001; 141(1):78-86. DOI: 10.1067/mhj.2001.111952. View

Minino A, Murphy S, Xu J, Kochanek K . Deaths: final data for 2008. Natl Vital Stat Rep. 2012; 59(10):1-126. View

Jeannine Brady L, Maddocks S, Larson M, Forsgren N, Persson K, Deivanayagam C . The changing faces of Streptococcus antigen I/II polypeptide family adhesins. Mol Microbiol. 2010; 77(2):276-86. PMC: 2909373. DOI: 10.1111/j.1365-2958.2010.07212.x. View

Sillanpaa J, Nallapareddy S, Singh K, Ferraro M, Murray B . Adherence characteristics of endocarditis-derived Streptococcus gallolyticus ssp. gallolyticus (Streptococcus bovis biotype I) isolates to host extracellular matrix proteins. FEMS Microbiol Lett. 2008; 289(1):104-9. DOI: 10.1111/j.1574-6968.2008.01378.x. View

10.

Zhu L, Kreth J, Cross S, Gimzewski J, Shi W, Qi F . Functional characterization of cell-wall-associated protein WapA in Streptococcus mutans. Microbiology (Reading). 2006; 152(Pt 8):2395-2404. DOI: 10.1099/mic.0.28883-0. View

11.

Foster T, Geoghegan J, Ganesh V, Hook M . Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus. Nat Rev Microbiol. 2013; 12(1):49-62. PMC: 5708296. DOI: 10.1038/nrmicro3161. View

12.

Nobbs A, Rosini R, Rinaudo C, Maione D, Grandi G, Telford J . Sortase A utilizes an ancillary protein anchor for efficient cell wall anchoring of pili in Streptococcus agalactiae. Infect Immun. 2008; 76(8):3550-60. PMC: 2493207. DOI: 10.1128/IAI.01613-07. View

13.

Nobbs A, Lamont R, Jenkinson H . Streptococcus adherence and colonization. Microbiol Mol Biol Rev. 2009; 73(3):407-50, Table of Contents. PMC: 2738137. DOI: 10.1128/MMBR.00014-09. View

14.

Thuny F, Giorgi R, Habachi R, Ansaldi S, Le Dolley Y, Casalta J . Excess mortality and morbidity in patients surviving infective endocarditis. Am Heart J. 2012; 164(1):94-101. DOI: 10.1016/j.ahj.2012.04.003. View

15.

Oliveira F, Forte C, Barros Silva P, Lopes C, Montenegro R, Santos A . Molecular Analysis of Oral Bacteria in Heart Valve of Patients With Cardiovascular Disease by Real-Time Polymerase Chain Reaction. Medicine (Baltimore). 2015; 94(47):e2067. PMC: 5058980. DOI: 10.1097/MD.0000000000002067. View

16.

Inoue H, Suzuki D, Asai K . A putative bactoprenol glycosyltransferase, CsbB, in Bacillus subtilis activates SigM in the absence of co-transcribed YfhO. Biochem Biophys Res Commun. 2013; 436(1):6-11. DOI: 10.1016/j.bbrc.2013.04.064. View

17.

Nallapareddy S, Qin X, Weinstock G, Hook M, Murray B . Enterococcus faecalis adhesin, ace, mediates attachment to extracellular matrix proteins collagen type IV and laminin as well as collagen type I. Infect Immun. 2000; 68(9):5218-24. PMC: 101781. DOI: 10.1128/IAI.68.9.5218-5224.2000. View

18.

Han Y, Wang X . Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res. 2013; 92(6):485-91. PMC: 3654760. DOI: 10.1177/0022034513487559. View

19.

Sato Y, Okamoto K, Kagami A, Yamamoto Y, Ohta K, Igarashi T . Application of in vitro mutagenesis to identify the gene responsible for cold agglutination phenotype of Streptococcus mutans. Microbiol Immunol. 2004; 48(6):449-56. DOI: 10.1111/j.1348-0421.2004.tb03535.x. View

20.

Dramsi S, Morello E, Poyart C, Trieu-Cuot P . Epidemiologically and clinically relevant Group B Streptococcus isolates do not bind collagen but display enhanced binding to human fibrinogen. Microbes Infect. 2012; 14(12):1044-8. DOI: 10.1016/j.micinf.2012.07.004. View