Neonatal Respiratory Syncytial Virus Infection Has an Effect on Lung Inflammation and the CD4(+) CD25(+) T Cell Subpopulation During Ovalbumin Sensitization in Adult Mice

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2016 Mar 19

PMID 26990762

Citations 1

Authors

A Comas-Garcia

C P Lopez-Pacheco

E A Garcia-Zepeda

G Soldevila

P Ramos-Martinez

J Ramos-Castaneda

Affiliations

Soon will be listed here.

Abstract

In BALB/c adult mice, respiratory syncytial virus (RSV) infection enhances the degree of lung inflammation before and/or after ovalbumin (OVA) respiratory sensitization. However, it is unclear whether RSV infection in newborn mice has an effect on the immune response to OVA respiratory sensitization in adult mice. The aim of this study was to determine if RSV neonatal infection alters T CD4(+) population and lung inflammation during OVA respiratory sensitization in adult mice. BALB/c mice were infected with RSV on the fourth day of life and challenged by OVA 4 weeks later. We found that in adult mice, RSV neonatal infection prior to OVA sensitization reduces the CD4(+) CD25(+) and CD4(+) CD25(+) forkhead protein 3 (FoxP3)(+) cell populations in the lungs and bronchoalveolar lavage. Furthermore, it also attenuates the inflammatory infiltrate and cytokine/chemokine expression levels in the mouse airways. In conclusion, the magnitude of the immune response to a non-viral respiratory perturbation in adult mice is not enhanced by a neonatal RSV infection.

Citing Articles

Ultrastructural and Functional Characterization of Mitochondrial Dynamics Induced by Human Respiratory Syncytial Virus Infection in HEp-2 Cells.

Lara-Hernandez I, Munoz-Escalante J, Bernal-Silva S, Noyola D, Wong-Chew R, Comas-Garcia A Viruses. 2023; 15(7).

PMID: 37515204 PMC: 10386036. DOI: 10.3390/v15071518.

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