Castleman's Disease of a Submandibular Mass Diagnosed on Fine Needle Cytology: Report of a Case with Histopathological, Immunocytochemical and Imaging Correlations

Overview

Journal Intractable Rare Dis Res

Date 2016 Mar 19

PMID 26989647

Citations 4

Authors

Maria Gabriella Malzone

Anna Cipolletta Campanile

Veronica Sanna

Franco Ionna

Francesco Longo

Annarosaria De Chiara

Sergio Venanzio Setola

Gerardo Botti

Franco Fulciniti

Affiliations

Soon will be listed here.

Abstract

Castleman's disease (CD) is an unusual inflammatory lymphoproliferative disorder of uncertain aetiology, mainly involving lymphatic tissue in the mediastinum, but also occurring in the neck, lung, abdomen, pelvis, skeletal muscle and retroperitoneum. Fine Needle Cytology (FNC) is a quick, cost-effective and safe diagnostic modality to investigate on organs involved by CD, also providing a guide to treatment and management of patients with lymphoadenopathy. We report a case of a 44-year-old man who underwent FNC of a submandibular mass with subsequent surgical excision. Cytology revealed an atypical lymphoproliferative process, which arose the suspicion of CD. Histopathological study of the excised masses combined with immunhistochemistry and imaging of the submandibular and neck areas, confirmed the suspicion. A final diagnosis of Unicentric Castleman's disease, hyaline-vascular type, was made.

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