Association of the Transcription Factor 7 Like 2 (TCF7L2) Polymorphism With Diabetic Nephropathy Risk: A Meta-Analysis

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2016 Mar 18

PMID 26986145

Citations 3

Authors

Zhenqian Fan

Qiliang Cai

Yu Chen

Xuying Meng

Fenglin Cao

Shaoxiong Zheng

Jianchao Guo

Affiliations

Soon will be listed here.

Abstract

It is assumed that genetic factors may participate in the development of diabetic nephropathy (DN). The association between TCF7L2 gene polymorphism and DN risk is still unclear. To evaluate the relationship, we performed this meta-analysis. Eligible relevant studies were searched and selected from PubMed, Embase, and ISI Web of Science. Summary effect estimates were derived using a random effects model, with attention to study quality and publication bias. Ethnical approval was not necessary, because this meta-analysis was based on published articles, and did not involve patient consent. A total of 7 studies were identified. Analysis of all studies indicated significant association between TCF7L2 gene polymorphism and DN risk (odds ratio [OR] = 1.31, 95% confidence interval (CI) = 1.10-1.56, Pheterogeneity < 0.00001, P = 0.002). Subgroup analysis showed similar results in Asian (OR = 1.33, 95% CI = 1.10-1.62, Pheterogeneity = 0.03, P = 0.004), in Caucasian (OR = 2.27, 95% CI = 1.78-2.90, Pheterogeneity = 0.17, P < 0.00001), in rs7903146 mutation (OR = 1.61, 95% CI = 1.25-2.07, Pheterogeneity < 0.00001, P = 0.0002), However, no association was observed in Negroid (OR = 1.10, 95% CI = 0.90-1.35, Pheterogeneity < 00001, P = 0.36). Our results suggest that TCF7L2 gene polymorphism may contribute to the risk of DN. However, more studies should be launched in the future.

Citing Articles

Transcription factor 7-like 2 gene- smoking interaction on the risk of diabetic nephropathy in Chinese Han population.

Xue P, Cao H, Ma Z, Zhou Y, Wang N Genes Environ. 2021; 43(1):26.

PMID: 34193317 PMC: 8244137. DOI: 10.1186/s41021-021-00194-2.

Association between angiotensinogen T174M polymorphism and the risk of diabetic nephropathy: A meta-analysis.

Liu N, Wang Y J Renin Angiotensin Aldosterone Syst. 2019; 20(1):1470320318823927.

PMID: 30798724 PMC: 6350140. DOI: 10.1177/1470320318823927.

The Susceptibility Genes in Diabetic Nephropathy.

Wei L, Xiao Y, Li L, Xiong X, Han Y, Zhu X Kidney Dis (Basel). 2018; 4(4):226-237.

PMID: 30574499 PMC: 6276750. DOI: 10.1159/000492633.

References

Lewis J, Palmer N, Hicks P, Sale M, Langefeld C, Freedman B . Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies. Diabetes. 2008; 57(8):2220-5. PMC: 2494685. DOI: 10.2337/db07-1319. View

Ma E, Wang H, Guo J, Tian R, Wei L . The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis. Clinics (Sao Paulo). 2015; 70(8):593-9. PMC: 4518842. DOI: 10.6061/clinics/2015(08)10. View

Buraczynska M, Zukowski P, Ksiazek P, Kuczmaszewska A, Janicka J, Zaluska W . Transcription factor 7-like 2 (TCF7L2) gene polymorphism and clinical phenotype in end-stage renal disease patients. Mol Biol Rep. 2014; 41(6):4063-8. PMC: 4033800. DOI: 10.1007/s11033-014-3275-6. View

Fu L, Lin Y, Yang Z, Yin Y . [Association analysis of genetic polymorphisms of TCF7L2, CDKAL1, SLC30A8, HHEX genes and microvascular complications of type 2 diabetes mellitus]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012; 29(2):194-9. DOI: 10.3760/cma.j.issn.1003-9406.2012.02.017. View

Grant S, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J . Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet. 2006; 38(3):320-3. DOI: 10.1038/ng1732. View

Hussain H, Ramachandran V, Ravi S, Sajan T, Ehambaram K, Gurramkonda V . TCF7L2 rs7903146 polymorphism and diabetic nephropathy association is not independent of type 2 diabetes--a study in a south Indian population and meta-analysis. Endokrynol Pol. 2014; 65(4):298-305. DOI: 10.5603/EP.2014.0041. View

Zhai Y, Zhao J, You H, Pang C, Yin L, Guo T . Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population. Meta Gene. 2015; 2:332-41. PMC: 4287822. DOI: 10.1016/j.mgene.2014.04.006. View

Buraczynska M, Swatowski A, Markowska-Gosik D, Kuczmaszewska A, Ksiazek A . Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients. Diabetes Res Clin Pract. 2011; 93(3):390-5. DOI: 10.1016/j.diabres.2011.05.017. View

Coresh J, Selvin E, Stevens L, Manzi J, Kusek J, Eggers P . Prevalence of chronic kidney disease in the United States. JAMA. 2007; 298(17):2038-47. DOI: 10.1001/jama.298.17.2038. View

10.

Mitchell R, Mondragon A, Chen L, McGinty J, French P, Ferrer J . Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass. Hum Mol Genet. 2014; 24(5):1390-9. PMC: 4321446. DOI: 10.1093/hmg/ddu553. View

11.

Xu Y, Wang L, He J, Bi Y, Li M, Wang T . Prevalence and control of diabetes in Chinese adults. JAMA. 2013; 310(9):948-59. DOI: 10.1001/jama.2013.168118. View

12.

Yao H, Wang Z, Wang T, Ma Y, Su Y, Ma Q . Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China. Int J Environ Res Public Health. 2015; 12(9):11797-814. PMC: 4586708. DOI: 10.3390/ijerph120911797. View

13.

Moran Y, Labrador L, Camargo M, Fernandez D, Chiurillo M . Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans. Arch Endocrinol Metab. 2015; 60(3):246-51. PMC: 10522308. DOI: 10.1590/2359-3997000000064. View

14.

Buchbinder S, Rudofsky Jr G, Humpert P, Schilling T, Zorn M, Bierhaus A . The DG10S478 variant in the TCF7L2 gene is not associated with microvascular complications in type 2 diabetes. Exp Clin Endocrinol Diabetes. 2007; 116(4):211-4. DOI: 10.1055/s-2007-993149. View

15.

Eboh C, Chowdhury T . Management of diabetic renal disease. Ann Transl Med. 2015; 3(11):154. PMC: 4499663. DOI: 10.3978/j.issn.2305-5839.2015.06.25. View

16.

Jia W, Gao X, Pang C, Hou X, Bao Y, Liu W . Prevalence and risk factors of albuminuria and chronic kidney disease in Chinese population with type 2 diabetes and impaired glucose regulation: Shanghai diabetic complications study (SHDCS). Nephrol Dial Transplant. 2009; 24(12):3724-31. DOI: 10.1093/ndt/gfp349. View

17.

Hayashi T, Iwamoto Y, Kaku K, Hirose H, Maeda S . Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population. Diabetologia. 2007; 50(5):980-4. DOI: 10.1007/s00125-007-0618-z. View

18.

Parving H, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P . The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med. 2001; 345(12):870-8. DOI: 10.1056/NEJMoa011489. View

19.

Quaglia M, Terrazzino S, Musetti C, Cargnin S, Merlotti G, Cena T . The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant: Results From a Single-Center Cohort and Meta-Analysis of the Literature. Transplantation. 2015; 100(8):1750-8. DOI: 10.1097/TP.0000000000000978. View

20.

Wu L, Hsieh C, Pei D, Hung Y, Kuo S, Lin E . Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPARgamma and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes. Nephrol Dial Transplant. 2009; 24(11):3360-6. DOI: 10.1093/ndt/gfp271. View