Structural and Biophysical Characteristics of Human Skin in Maintaining Proper Epidermal Barrier Function

Overview

Journal Postepy Dermatol Alergol

Publisher Termedia

Specialty Allergy & Immunology

Date 2016 Mar 18

PMID 26985171

Citations 99

Authors

Magdalena Boer

Ewa Duchnik

Romuald Maleszka

Mariola Marchlewicz

Affiliations

Soon will be listed here.

Abstract

The complex structure of human skin and its physicochemical properties turn it into an efficient outermost defence line against exogenous factors, and help maintain homeostasis of the human body. This role is played by the epidermal barrier with its major part - stratum corneum. The condition of the epidermal barrier depends on individual and environmental factors. The most important biophysical parameters characterizing the status of this barrier are the skin pH, epidermal hydration, transepidermal water loss and sebum excretion. The knowledge of biophysical skin processes may be useful for the implementation of prophylactic actions whose aim is to restore the barrier function.

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