MicroRNA-203 Suppresses Gastric Cancer Growth by Targeting PIBF1/Akt Signaling

Overview

Journal J Exp Clin Cancer Res

Publisher Biomed Central

Specialty Oncology

Date 2016 Mar 17

PMID 26980572

Citations 10

Authors

Shao-Jun Chu

Ge Wang

Peng-Fei Zhang

Rui Zhang

Yan-Xia Huang

Yun-Min Lu

Wei Da

Qun Sun

Jing Zhang

Jin-Shui Zhu

Affiliations

Soon will be listed here.

Abstract

Background: MicroRNAs (miRNAs) have been proved involved in many tumorigenic behaviors including tumor growth. But, the clinical significance and functions of miRNA-203 in gastric cancer (GC) remain elusive.

Results: Decreased expression of miRNA-203 was correlated with tumor size, poor prognosis and recurrence in GC patients. Overexpression of miR-203 or knockdown of its target progesterone immunomodulatory binding factor 1 (PIBF1) inhibited GC growth in vitro and in vivo, while miR-203 knockdown promoted GC proliferation. In addition, PIBF1 overexpression attenuated the inhibitory effects of miR-203 on GC growth and enhanced that effect on p-Akt expression.

Conclusions: MiR-203 as a tumor biomarker suppresses GC growth through targeting the PIBF1/Akt signaling, suggesting that it may have the important therapeutic potential for the treatment of GC.

Citing Articles

MicroRNA-203 restrains epithelial-mesenchymal transition, invasion and migration of papillary thyroid cancer by downregulating AKT3.

You A, Fu L, Li Y, Li X, You B Cell Cycle. 2020; 19(10):1105-1121.

PMID: 32308106 PMC: 7217351. DOI: 10.1080/15384101.2020.1746490.

Diagnostic and prognostic significance of serum miR-203 in patients with acute myeloid leukemia.

Zheng Z, Rong G, Li G, Ren F, Ma Y Int J Clin Exp Pathol. 2020; 12(5):1548-1556.

PMID: 31933972 PMC: 6947105.

MiR-203 acts as a radiosensitizer of gastric cancer cells by directly targeting ZEB1.

Jiang Y, Jin S, Tan S, Shen Q, Xue Y Onco Targets Ther. 2019; 12:6093-6104.

PMID: 31440062 PMC: 6679680. DOI: 10.2147/OTT.S197539.

Clinical significance of serum MicroRNA-203 in patients with acute myeloid leukemia.

Guo Y Bioengineered. 2019; 10(1):345-352.

PMID: 31411110 PMC: 6738448. DOI: 10.1080/21655979.2019.1652490.

Identifying cancer-related microRNAs based on subpathways.

Liu W, Cui Z, Zan X IET Syst Biol. 2018; 12(6):273-278.

PMID: 30472691 PMC: 8687160. DOI: 10.1049/iet-syb.2018.5025.

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