Clipping the Wings of Glioblastoma: Modulation of WNT As a Novel Therapeutic Strategy

Overview

Journal J Neuropathol Exp Neurol

Publisher Oxford University Press

Specialties Neurology
Pathology

Date 2016 Mar 17

PMID 26979081

Citations 25

Authors

Abigail K Suwala

Allison Hanaford

Ulf D Kahlert

Jaroslaw Maciaczyk

Affiliations

Soon will be listed here.

Abstract

Glioblastoma (GBM) is the most malignant brain tumor and has a dismal prognosis. Aberrant WNT signaling is known to promote glioma cell growth and dissemination and resistance to conventional radio- and chemotherapy. Moreover, a population of cancer stem-like cells that promote glioma growth and recurrence are strongly dependent on WNT signaling. Here, we discuss the role and mechanisms of aberrant canonical and noncanonical WNT signaling in GBM. We present current clinical approaches aimed at modulating WNT activity and evaluate their clinical perspective as a novel treatment option for GBM.

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