Protein Intake in Early Childhood and Body Composition at the Age of 6 Years: The Generation R Study

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2016 Mar 16

PMID 26975442

Citations 29

Authors

T Voortman

K V E Braun

J C Kiefte-de Jong

V W V Jaddoe

O H Franco

E H van den Hooven

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies suggest that high protein intake in infancy leads to a higher body mass index (BMI) in later childhood. We examined the associations of total, animal and vegetable protein intake in early childhood with detailed measures of body composition at the age of 6 years.

Methods: This study was performed in 2911 children participating in a population-based cohort study. Protein intake at the age of 1 year was assessed with a validated food-frequency questionnaire and was adjusted for total energy intake. At the children's age of 6 years, we measured their anthropometrics and body fat (with dual-energy X-ray absorptiometry). We calculated age- and sex-specific s.d. scores for BMI, fat mass index (FMI) and fat-free mass index (FFMI).

Results: After adjustment for confounders, a 10 g per day higher total protein intake at 1 year of age was associated with a 0.05 s.d. (95% confidence interval (CI) 0.00, 0.09) higher BMI at age 6. This association was fully driven by a higher FMI (0.06 s.d. (95%CI 0.01, 0.11)) and not FFMI (-0.01 s.d. (95%CI -0.06, 0.05)). The associations of protein intake with FMI at 6 years remained significant after adjustment for BMI at the age of 1 year. Additional analyses showed that the associations of protein intake with FMI were stronger in girls than in boys (P for interaction=0.03), stronger among children who had catch-up growth in the first year of life (P for interaction<0.01) and stronger for intake of animal protein (both dairy and non-dairy protein) than protein from vegetable sources.

Conclusions: Our results suggest that high protein intake in early childhood is associated with higher body fat mass, but not fat-free mass. Future studies are needed to investigate whether these changes persist into adulthood and to examine the optimal range of protein intake for infants and young children.

Citing Articles

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Association between protein-to-energy ratio and overweight/obesity in children and adolescents in the United States: a cross-sectional study based on NHANES.

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Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium.

El Sharkawy M, Felix J, Grote V, Voortman T, Jaddoe V, Koletzko B Epigenetics. 2024; 19(1):2299045.

PMID: 38198623 PMC: 10793674. DOI: 10.1080/15592294.2023.2299045.

Effects of early introduction of solid foods on nutrient intake in preterm infants during their 1st year of life: a secondary outcome analysis of a prospective, randomized intervention study.

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Milk-cereal mix supplementation during infancy and impact on neurodevelopmental outcomes at 12 and 24 months of age: a randomised controlled trial in India.

Upadhyay R, Taneja S, Strand T, Hysing M, Koshy B, Bhandari N Br J Nutr. 2022; 130(5):868-877.

PMID: 36539339 PMC: 10404480. DOI: 10.1017/S0007114522003944.

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