Pharmacological and Non-pharmacological Treatment Options for Depression and Depressive Symptoms in Hemodialysis Patients

Overview

Journal Health Psychol Res

Date 2016 Mar 15

PMID 26973957

Citations 6

Authors

Stefania S Grigoriou

Christina Karatzaferi

Giorgos K Sakkas

Affiliations

Soon will be listed here.

Abstract

Depression is a mental disorder with a high prevalence among patients with end stage renal disease (ESRD). It is reported that depression afflicts approximately 20-30% of this patient population, being associated, amongst other, with high mortality rate, low adherence to medication and low perceived quality of life. There is a variety of medications known to be effective for the treatment of depression but due to poor adherence to treatment as well as due to the high need for medications addressing other ESRD comorbidities, depression often remains untreated. According to the literature, depression is under-diagnosed and undertreated in the majority of the patients with chronic kidney disease. In the current review the main pharmacological and non-pharmacological approaches and research outcomes for the management of depressive symptoms in hemodialysis patients are discussed.

Citing Articles

Effects of exercise dose based on the ACSM recommendations on depression in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.

Fang Y, Xiaoling B, Huan L, Yaping G, Binying Z, Man W Front Physiol. 2025; 15:1513746.

PMID: 39959813 PMC: 11825786. DOI: 10.3389/fphys.2024.1513746.

The effect of recreational therapy application on depression in hemodialysis patients: a randomized clinical trial.

Alishahi M, Mohajer S, Namazinia M, Mazloum S Int Urol Nephrol. 2024; 57(2):585-594.

PMID: 39259395 DOI: 10.1007/s11255-024-04201-7.

Depression Among Hemodialysis Patients: Related Factors and the Impact of Insomnia and Fatigue.

Sakiqi J, Vasilopoulos G, Koutelekos I, Polikandrioti M, Dousis E, Pavlatou N Cureus. 2022; 14(5):e25254.

PMID: 35755568 PMC: 9217109. DOI: 10.7759/cureus.25254.

Influence of Depression and Anxiety on Hemodialysis Patients: The Value of Multidisciplinary Care.

Delgado-Dominguez C, Sanz-Gomez S, Lopez-Herradon A, Diaz Espejo B, Lamas Gonzalez O, de Los Santos Roig M Int J Environ Res Public Health. 2021; 18(7).

PMID: 33805492 PMC: 8036719. DOI: 10.3390/ijerph18073544.

Management of anxiety and depression in haemodialysis patients: the role of non-pharmacological methods.

Gerogianni G, Babatsikou F, Polikandrioti M, Grapsa E Int Urol Nephrol. 2018; 51(1):113-118.

PMID: 30456545 DOI: 10.1007/s11255-018-2022-7.

References

Kimmel P . Psychosocial factors in dialysis patients. Kidney Int. 2001; 59(4):1599-613. DOI: 10.1046/j.1523-1755.2001.0590041599.x. View

Theofilou P . Medication adherence in Greek hemodialysis patients: the contribution of depression and health cognitions. Int J Behav Med. 2012; 20(2):311-8. DOI: 10.1007/s12529-012-9231-8. View

Kessler R, Berglund P, Demler O, Jin R, Koretz D, Merikangas K . The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003; 289(23):3095-105. DOI: 10.1001/jama.289.23.3095. View

Kimmel P, Peterson R . Depression in patients with end-stage renal disease treated with dialysis: has the time to treat arrived?. Clin J Am Soc Nephrol. 2007; 1(3):349-52. DOI: 10.2215/CJN.00890306. View

Drayer R, Mulsant B, Lenze E, Rollman B, Dew M, Kelleher K . Somatic symptoms of depression in elderly patients with medical comorbidities. Int J Geriatr Psychiatry. 2005; 20(10):973-82. DOI: 10.1002/gps.1389. View

Kouidi E, Karagiannis V, Grekas D, Iakovides A, Kaprinis G, Tourkantonis A . Depression, heart rate variability, and exercise training in dialysis patients. Eur J Cardiovasc Prev Rehabil. 2009; 17(2):160-7. DOI: 10.1097/HJR.0b013e32833188c4. View

Chilcot J, Wellsted D, Da Silva-Gane M, Farrington K . Depression on dialysis. Nephron Clin Pract. 2008; 108(4):c256-64. DOI: 10.1159/000124749. View

Spitzer R, Kroenke K, Williams J . Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999; 282(18):1737-44. DOI: 10.1001/jama.282.18.1737. View

Kim K, Lee M, Sok S . [The effect of music therapy on anxiety and depression in patients undergoing hemodialysis]. Taehan Kanho Hakhoe Chi. 2006; 36(2):321-9. DOI: 10.4040/jkan.2006.36.2.321. View

10.

Duarte P, Miyazaki M, Blay S, Sesso R . Cognitive-behavioral group therapy is an effective treatment for major depression in hemodialysis patients. Kidney Int. 2009; 76(4):414-21. DOI: 10.1038/ki.2009.156. View

11.

Finkelstein F, Wuerth D, Finkelstein S . Health related quality of life and the CKD patient: challenges for the nephrology community. Kidney Int. 2009; 76(9):946-52. DOI: 10.1038/ki.2009.307. View

12.

Cohen S, Norris L, Acquaviva K, Peterson R, Kimmel P . Screening, diagnosis, and treatment of depression in patients with end-stage renal disease. Clin J Am Soc Nephrol. 2007; 2(6):1332-42. DOI: 10.2215/CJN.03951106. View

13.

Araujo S, de Bruin V, Daher E, Almeida G, Medeiros C, de Bruin P . Risk factors for depressive symptoms in a large population on chronic hemodialysis. Int Urol Nephrol. 2011; 44(4):1229-35. DOI: 10.1007/s11255-011-0032-9. View

14.

Garcia-Lizana F, Munoz-Mayorga I . Telemedicine for depression: a systematic review. Perspect Psychiatr Care. 2010; 46(2):119-26. DOI: 10.1111/j.1744-6163.2010.00247.x. View

15.

Symister P, Friend R . The influence of social support and problematic support on optimism and depression in chronic illness: a prospective study evaluating self-esteem as a mediator. Health Psychol. 2003; 22(2):123-9. DOI: 10.1037//0278-6133.22.2.123. View

16.

Lin Y, Lu K, Chen C, Chang C . The effects of music as therapy on the overall well-being of elderly patients on maintenance hemodialysis. Biol Res Nurs. 2011; 14(3):277-85. DOI: 10.1177/1099800411413259. View

17.

Lopes A, Albert J, Young E, Satayathum S, Pisoni R, Andreucci V . Screening for depression in hemodialysis patients: associations with diagnosis, treatment, and outcomes in the DOPPS. Kidney Int. 2004; 66(5):2047-53. DOI: 10.1111/j.1523-1755.2004.00977.x. View

18.

Rai M, Rustagi T, Rustagi S, Kohli R . Depression, insomnia and sleep apnea in patients on maintenance hemodialysis. Indian J Nephrol. 2011; 21(4):223-9. PMC: 3193663. DOI: 10.4103/0971-4065.83028. View

19.

Patel S, Shah V, Peterson R, Kimmel P . Psychosocial variables, quality of life, and religious beliefs in ESRD patients treated with hemodialysis. Am J Kidney Dis. 2002; 40(5):1013-22. DOI: 10.1053/ajkd.2002.36336. View

20.

Miskulin D, Athienites N, Yan G, Martin A, Ornt D, Kusek J . Comorbidity assessment using the Index of Coexistent Diseases in a multicenter clinical trial. Kidney Int. 2001; 60(4):1498-510. DOI: 10.1046/j.1523-1755.2001.00954.x. View