RECENT DEVELOPMENTS IN ELECTROCHEMICAL SENSORS FOR THE DETECTION OF NEUROTRANSMITTERS FOR APPLICATIONS IN BIOMEDICINE

Overview

Journal Anal Lett

Specialty Chemistry

Date 2016 Mar 15

PMID 26973348

Citations 8

Authors

Rifat Emrah Ozel

Akhtar Hayat

Silvana Andreescu

Affiliations

Soon will be listed here.

Abstract

Neurotransmitters are important biological molecules that are essential to many neurophysiological processes including memory, cognition, and behavioral states. The development of analytical methodologies to accurately detect neurotransmitters is of great importance in neurological and biological research. Specifically designed microelectrodes or microbiosensors have demonstrated potential for rapid, real-time measurements with high spatial resolution. Such devices can facilitate study of the role and mechanism of action of neurotransmitters and can find potential uses in biomedicine. This paper reviews the current status and recent advances in the development and application of electrochemical sensors for the detection of small-molecule neurotransmitters. Measurement challenges and opportunities of electroanalytical methods to advance study and understanding of neurotransmitters in various biological models and disease conditions are discussed.

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References

Yap C, Xu G, Ang S . Amperometric nitric oxide sensor based on nanoporous platinum phthalocyanine modified electrodes. Anal Chem. 2012; 85(1):107-13. DOI: 10.1021/ac302081h. View

Blank C, Murrill E, Adams R . Central nervous system effects of 6-aminodopamine and 6-hydroxydopamine. Brain Res. 1972; 45(2):635-7. DOI: 10.1016/0006-8993(72)90497-0. View

Ozel R, Wallace K, Andreescu S . Chitosan coated carbon fiber microelectrode for selective in vivo detection of neurotransmitters in live zebrafish embryos. Anal Chim Acta. 2011; 695(1-2):89-95. PMC: 3100530. DOI: 10.1016/j.aca.2011.03.057. View

Cosnier S, Innocent C, Allien L, Poitry S, Tsacopoulos M . An electrochemical method for making enzyme microsensors. Application to the detection of dopamine and glutamate. Anal Chem. 2011; 69(5):968-71. DOI: 10.1021/ac960841h. View

Mohammad-Zadeh L, Moses L, Gwaltney-Brant S . Serotonin: a review. J Vet Pharmacol Ther. 2008; 31(3):187-99. DOI: 10.1111/j.1365-2885.2008.00944.x. View

Hawkins C, Davies M . Detection and characterisation of radicals in biological materials using EPR methodology. Biochim Biophys Acta. 2013; 1840(2):708-21. DOI: 10.1016/j.bbagen.2013.03.034. View

Chen X, Tian X, Shin I, Yoon J . Fluorescent and luminescent probes for detection of reactive oxygen and nitrogen species. Chem Soc Rev. 2011; 40(9):4783-804. DOI: 10.1039/c1cs15037e. View

Swamy B, Venton B . Carbon nanotube-modified microelectrodes for simultaneous detection of dopamine and serotonin in vivo. Analyst. 2007; 132(9):876-84. DOI: 10.1039/b705552h. View

Ozel R, Ispas C, Ganesana M, Leiter J, Andreescu S . Glutamate oxidase biosensor based on mixed ceria and titania nanoparticles for the detection of glutamate in hypoxic environments. Biosens Bioelectron. 2013; 52:397-402. PMC: 3831270. DOI: 10.1016/j.bios.2013.08.054. View

10.

Robinson D, Venton B, Heien M, Wightman R . Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clin Chem. 2003; 49(10):1763-73. DOI: 10.1373/49.10.1763. View

11.

Goriushkina T, Soldatkin A, Dzyadevych S . Application of amperometric biosensors for analysis of ethanol, glucose, and lactate in wine. J Agric Food Chem. 2009; 57(15):6528-35. DOI: 10.1021/jf9009087. View

12.

Akyilmaz E, Turemis M, Yasa I . Voltammetric determination of epinephrine by White rot fungi (Phanerochaete chrysosporium ME446) cells based microbial biosensor. Biosens Bioelectron. 2010; 26(5):2590-4. DOI: 10.1016/j.bios.2010.11.012. View

13.

Batra B, Pundir C . An amperometric glutamate biosensor based on immobilization of glutamate oxidase onto carboxylated multiwalled carbon nanotubes/gold nanoparticles/chitosan composite film modified Au electrode. Biosens Bioelectron. 2013; 47:496-501. DOI: 10.1016/j.bios.2013.03.063. View

14.

Ganesana M, Erlichman J, Andreescu S . Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cytochrome c biosensor. Free Radic Biol Med. 2012; 53(12):2240-9. PMC: 3565046. DOI: 10.1016/j.freeradbiomed.2012.10.540. View

15.

Tembe S, Karve M, Inamdar S, Haram S, Melo J, DSouza S . Development of electrochemical biosensor based on tyrosinase immobilized in composite biopolymeric film. Anal Biochem. 2005; 349(1):72-7. DOI: 10.1016/j.ab.2005.11.016. View

16.

Manocha M, Khan W . Serotonin and GI Disorders: An Update on Clinical and Experimental Studies. Clin Transl Gastroenterol. 2012; 3:e13. PMC: 3365677. DOI: 10.1038/ctg.2012.8. View

17.

Coneski P, Schoenfisch M . Nitric oxide release: part III. Measurement and reporting. Chem Soc Rev. 2012; 41(10):3753-8. PMC: 3341472. DOI: 10.1039/c2cs15271a. View

18.

Njagi J, Chernov M, Leiter J, Andreescu S . Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor. Anal Chem. 2010; 82(3):989-96. DOI: 10.1021/ac9022605. View

19.

Chen W, Cai S, Ren Q, Wen W, Zhao Y . Recent advances in electrochemical sensing for hydrogen peroxide: a review. Analyst. 2011; 137(1):49-58. DOI: 10.1039/c1an15738h. View

20.

Freeman R, Elbaz J, Gill R, Zayats M, Willner I . Analysis of dopamine and tyrosinase activity on ion-sensitive field-effect transistor (ISFET) devices. Chemistry. 2007; 13(26):7288-93. DOI: 10.1002/chem.200700734. View