Comparison Between New-Onset and Old-Diagnosed Type 2 Diabetes with Ketosis in Rural Regions of China

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2016 Mar 12

PMID 26966435

Citations 1

Authors

Shichun Du

Xia Yang

Degang Shi

Qing Su

Affiliations

Soon will be listed here.

Abstract

Objectives. Type 2 diabetes (T2D) with ketosis was common because of late diagnosis and lacking adequate treatment in rural regions of China. This study aimed to provide the data of T2D with ketosis among inpatients in a south-west border city of China. Methods. Data of 371 patients of T2D with ketosis who were hospitalized between January 2011 and July 2015 in Baoshan People's Hospital, Yunnan, China, were analyzed. New-onset and old-diagnosed T2D patients presenting with ketosis were compared according to clinical characteristics, laboratory results, and chronic diabetic complications. Results. Overall, the blood glucose control was poor in our study subjects. Male predominated in both groups (male prevalence was 68% in new-onset and 64% in old-diagnosed groups). Overweight and obesity accounted for 50% in new-onset and 46% in old-diagnosed cases. Inducements of ketosis were 13.8% in new-onset and 38.7% in old-diagnosed patients. Infections were the first inducements in both groups. The prevalence of chronic complications of diabetes was common in both groups. Conclusions. More medical supports were needed for the early detection and adequate treatment of diabetes in rural areas of China.

Citing Articles

A systematic analysis on prevalence and sub-regional distribution of undiagnosed diabetes mellitus among adults in African countries.

Dessie G, Mulugeta H, Amare D, Negesse A, Wagnew F, Getaneh T J Diabetes Metab Disord. 2021; 19(2):1931-1941.

PMID: 33553047 PMC: 7843872. DOI: 10.1007/s40200-020-00635-9.

References

Tan H, Zhou Y, Yu Y . Characteristics of diabetic ketoacidosis in Chinese adults and adolescents -- a teaching hospital-based analysis. Diabetes Res Clin Pract. 2012; 97(2):306-12. DOI: 10.1016/j.diabres.2012.05.004. View

Hu D, Fu P, Xie J, Chen C, Yu D, Whelton P . Increasing prevalence and low awareness, treatment and control of diabetes mellitus among Chinese adults: the InterASIA study. Diabetes Res Clin Pract. 2008; 81(2):250-7. DOI: 10.1016/j.diabres.2008.04.008. View

Unnikrishnan R, Mohan V . Why screening for type 2 diabetes is necessary even in poor resource settings. J Diabetes Complications. 2015; 29(7):961-4. DOI: 10.1016/j.jdiacomp.2015.05.011. View

Chen C, Lu F . The guidelines for prevention and control of overweight and obesity in Chinese adults. Biomed Environ Sci. 2005; 17 Suppl:1-36. View

Blouin K, Boivin A, Tchernof A . Androgens and body fat distribution. J Steroid Biochem Mol Biol. 2007; 108(3-5):272-80. DOI: 10.1016/j.jsbmb.2007.09.001. View

Bevilacqua S, Bonadonna R, Buzzigoli G, Boni C, Ciociaro D, Maccari F . Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metabolism. 1987; 36(5):502-6. DOI: 10.1016/0026-0495(87)90051-5. View

Goodstein G, Milanesi A, Weinreb J . Ketosis-prone type 2 diabetes in a veteran population. Diabetes Care. 2014; 37(4):e74-5. PMC: 4392899. DOI: 10.2337/dc13-2824. View

Litonjua P, Raskin P . Idiopathic type 1 diabetes in Dallas, Texas: a 5-year experience. Diabetes Care. 2001; 24(6):1014-8. DOI: 10.2337/diacare.24.6.1014. View

Xu Y, Wang L, He J, Bi Y, Li M, Wang T . Prevalence and control of diabetes in Chinese adults. JAMA. 2013; 310(9):948-59. DOI: 10.1001/jama.2013.168118. View

10.

Umpierrez G, Smiley D, Robalino G, Peng L, Gosmanov A, Kitabchi A . Lack of lipotoxicity effect on {beta}-cell dysfunction in ketosis-prone type 2 diabetes. Diabetes Care. 2009; 33(3):626-31. PMC: 2827521. DOI: 10.2337/dc09-1369. View

11.

. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2003; 27 Suppl 1:S5-S10. DOI: 10.2337/diacare.27.2007.s5. View

12.

Yamada K, Nonaka K . Diabetic ketoacidosis in young obese Japanese men. Diabetes Care. 1996; 19(6):671. DOI: 10.2337/diacare.19.6.671a. View

13.

Winter W, Maclaren N, Riley W, CLARKE D, KAPPY M, Spillar R . Maturity-onset diabetes of youth in black Americans. N Engl J Med. 1987; 316(6):285-91. DOI: 10.1056/NEJM198702053160601. View

14.

Barski L, Nevzorov R, Jotkowitz A, Rabaev E, Zektser M, Zeller L . Comparison of diabetic ketoacidosis in patients with type-1 and type-2 diabetes mellitus. Am J Med Sci. 2013; 345(4):326-330. DOI: 10.1097/MAJ.0b013e31827424ab. View

15.

Boden G, Chen X, Rosner J, Barton M . Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes. 1995; 44(10):1239-42. DOI: 10.2337/diab.44.10.1239. View

16.

Louet J, Smith S, Gautier J, Molokhia M, Virally M, Kevorkian J . Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2007; 10(10):912-20. DOI: 10.1111/j.1463-1326.2007.00830.x. View

17.

Anjana R, Shanthirani C, Unnikrishnan R, Mugilan P, Amutha A, Divya Nair H . Regularity of follow-up, glycemic burden, and risk of microvascular complications in patients with type 2 diabetes: a 9-year follow-up study. Acta Diabetol. 2014; 52(3):601-9. DOI: 10.1007/s00592-014-0701-0. View

18.

Cao X, Zhang X, Xian Y, Wu J, Bao M, Yang Y . The diagnosis of diabetic acute complications using the glucose-ketone meter in outpatients at endocrinology department. Int J Clin Exp Med. 2015; 7(12):5701-5. PMC: 4307541. View

19.

Zhang M, Li Y, Cui W, Yang P, Li H, Sheng C . THE CLINICAL AND METABOLIC CHARACTERISTICS OF YOUNG-ONSET KETOSIS-PRONE TYPE 2 DIABETES IN CHINA. Endocr Pract. 2015; 21(12):1364-71. DOI: 10.4158/EP15778.OR. View

20.

Wang X, Tan H . Male predominance in ketosis-prone diabetes mellitus. Biomed Rep. 2015; 3(4):439-442. PMC: 4487040. DOI: 10.3892/br.2015.461. View