Raman Spectroscopy: Incorporating the Chemical Dimension into Dermatological Diagnosis

Overview

Journal Indian J Dermatol

Specialty Dermatology

Date 2016 Mar 9

PMID 26955087

Citations 1

Authors

Amit Sharma

Shruti Sharma

Anna Zarrow

Robert A Schwartz

W Clark Lambert

Affiliations

Soon will be listed here.

Abstract

Raman spectroscopy provides chemical analysis of tissue in vivo. By measuring the inelastic interactions of light with matter, Raman spectroscopy can determine the chemical composition of a sample. Diseases that are visually difficult to visually distinguish can be delineated based on differences in chemical composition of the affected tissue. Raman spectroscopy has successfully found spectroscopic signatures for skin cancers and differentiated those of benign skin growths. With current and on-going advances in optics and computing, inexpensive and effective Raman systems may soon be available for clinical use. Raman spectroscopy provides direct analyses of skin lesions, thereby improving both disease diagnosis and management.

Citing Articles

Rapid multi-task diagnosis of oral cancer leveraging fiber-optic Raman spectroscopy and deep learning algorithms.

Li X, Li L, Sun Q, Chen B, Zhao C, Dong Y Front Oncol. 2023; 13:1272305.

PMID: 37881489 PMC: 10597702. DOI: 10.3389/fonc.2023.1272305.

References

Schallreuter K, Moore J, Wood J, Beazley W, Gaze D, Tobin D . In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc. 1999; 4(1):91-6. DOI: 10.1038/sj.jidsp.5640189. View

Hata T, Scholz T, Ermakov I, McClane R, Khachik F, Gellermann W . Non-invasive raman spectroscopic detection of carotenoids in human skin. J Invest Dermatol. 2000; 115(3):441-8. DOI: 10.1046/j.1523-1747.2000.00060.x. View

Wohlrab J, Vollmann A, Wartewig S, Marsch W, Neubert R . Noninvasive characterization of human stratum corneum of undiseased skin of patients with atopic dermatitis and psoriasis as studied by Fourier transform Raman spectroscopy. Biopolymers. 2001; 62(3):141-6. DOI: 10.1002/bip.1006. View

Gniadecka M, Wulf H, Johansson C, Ullman S, Halberg P, Rossen K . Cutaneous tophi and calcinosis diagnosed in vivo by Raman spectroscopy. Br J Dermatol. 2001; 145(4):672-4. DOI: 10.1046/j.1365-2133.2001.04416.x. View

Nijssen A, Bakker Schut T, Heule F, Caspers P, Hayes D, Neumann M . Discriminating basal cell carcinoma from its surrounding tissue by Raman spectroscopy. J Invest Dermatol. 2002; 119(1):64-9. DOI: 10.1046/j.1523-1747.2002.01807.x. View

Caspers P, Williams A, Carter E, Edwards H, Barry B, Bruining H . Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal Raman spectroscopy. Pharm Res. 2002; 19(10):1577-80. DOI: 10.1023/a:1020481305420. View

Caspers P, Lucassen G, Puppels G . Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. Biophys J. 2003; 85(1):572-80. PMC: 1303112. DOI: 10.1016/S0006-3495(03)74501-9. View

Hasse S, Gibbons N, Rokos H, Marles L, Schallreuter K . Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress. J Invest Dermatol. 2004; 122(2):307-13. DOI: 10.1046/j.0022-202X.2004.22230.x. View

Gniadecka M, Philipsen P, Sigurdsson S, Wessel S, Nielsen O, Christensen D . Melanoma diagnosis by Raman spectroscopy and neural networks: structure alterations in proteins and lipids in intact cancer tissue. J Invest Dermatol. 2004; 122(2):443-9. DOI: 10.1046/j.0022-202X.2004.22208.x. View

10.

Osada M, Gniadecka M, Wulf H . Near-infrared Fourier transform Raman spectroscopic analysis of proteins, water and lipids in intact normal stratum corneum and psoriasis scales. Exp Dermatol. 2004; 13(6):391-5. DOI: 10.1111/j.0906-6705.2004.00169.x. View

11.

Sigurdsson S, Philipsen P, Hansen L, Larsen J, Gniadecka M, Wulf H . Detection of skin cancer by classification of Raman spectra. IEEE Trans Biomed Eng. 2004; 51(10):1784-93. DOI: 10.1109/TBME.2004.831538. View

12.

Choi J, Choo J, Chung H, Gweon D, Park J, Kim H . Direct observation of spectral differences between normal and basal cell carcinoma (BCC) tissues using confocal Raman microscopy. Biopolymers. 2005; 77(5):264-72. DOI: 10.1002/bip.20236. View

13.

Smith Z, Berger A . Surface-sensitive polarized Raman spectroscopy of biological tissue. Opt Lett. 2005; 30(11):1363-5. DOI: 10.1364/ol.30.001363. View

14.

Ko A, Choo-Smith L, Hewko M, Leonardi L, Sowa M, Dong C . Ex vivo detection and characterization of early dental caries by optical coherence tomography and Raman spectroscopy. J Biomed Opt. 2005; 10(3):031118. DOI: 10.1117/1.1915488. View

15.

Schallreuter K, Gibbons N, Zothner C, Elwary S, Rokos H, Wood J . Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun. 2006; 349(3):931-8. DOI: 10.1016/j.bbrc.2006.08.138. View

16.

Gibbons N, Wood J, Rokos H, Schallreuter K . Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2): potential and pitfalls. J Invest Dermatol. 2006; 126(12):2576-82. DOI: 10.1038/sj.jid.5700612. View

17.

Zhang G, Moore D, Sloan K, Flach C, Mendelsohn R . Imaging the prodrug-to-drug transformation of a 5-fluorouracil derivative in skin by confocal Raman microscopy. J Invest Dermatol. 2007; 127(5):1205-9. DOI: 10.1038/sj.jid.5700690. View

18.

Schallreuter K, Gibbons N, Zothner C, Abou Elloof M, Wood J . Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun. 2007; 360(1):70-5. DOI: 10.1016/j.bbrc.2007.05.218. View

19.

Nijssen A, Maquelin K, Santos L, Caspers P, Bakker Schut T, den Hollander J . Discriminating basal cell carcinoma from perilesional skin using high wave-number Raman spectroscopy. J Biomed Opt. 2007; 12(3):034004. DOI: 10.1117/1.2750287. View

20.

Huang W, Stoecker K, Griffiths R, Newbold L, Daims H, Whiteley A . Raman-FISH: combining stable-isotope Raman spectroscopy and fluorescence in situ hybridization for the single cell analysis of identity and function. Environ Microbiol. 2007; 9(8):1878-89. DOI: 10.1111/j.1462-2920.2007.01352.x. View