The Emerging Role of GATA Transcription Factors in Development and Disease

Overview

Journal Expert Rev Mol Med

Specialty General Medicine

Date 2016 Mar 9

PMID 26953528

Citations 102

Authors

Marjolein H F M Lentjes

Hanneke E C Niessen

Yoshimitsu Akiyama

Adriaan P de Bruine

Veerle Melotte

Manon van Engeland

Affiliations

Soon will be listed here.

Abstract

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

Citing Articles

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References

Caslini C, Capo-chichi C, Roland I, Nicolas E, Yeung A, Xu X . Histone modifications silence the GATA transcription factor genes in ovarian cancer. Oncogene. 2006; 25(39):5446-61. PMC: 7523731. DOI: 10.1038/sj.onc.1209533. View

Lepore J, Mericko P, Cheng L, Lu M, Morrisey E, Parmacek M . GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J Clin Invest. 2006; 116(4):929-39. PMC: 1409743. DOI: 10.1172/JCI27363. View

Parviz F, Matullo C, Garrison W, Savatski L, Adamson J, Ning G . Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet. 2003; 34(3):292-6. DOI: 10.1038/ng1175. View

Laforest B, Andelfinger G, Nemer M . Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011; 121(7):2876-87. PMC: 3223824. DOI: 10.1172/JCI44555. View

Kumar M, Hancock D, Molina-Arcas M, Steckel M, East P, Diefenbacher M . The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell. 2012; 149(3):642-55. DOI: 10.1016/j.cell.2012.02.059. View

Hitzler J, Cheung J, Li Y, Scherer S, Zipursky A . GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome. Blood. 2003; 101(11):4301-4. DOI: 10.1182/blood-2003-01-0013. View

Ludwig L, Gazda H, Eng J, Eichhorn S, Thiru P, Ghazvinian R . Altered translation of GATA1 in Diamond-Blackfan anemia. Nat Med. 2014; 20(7):748-53. PMC: 4087046. DOI: 10.1038/nm.3557. View

Kuo C, Morrisey E, Anandappa R, Sigrist K, Lu M, Parmacek M . GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997; 11(8):1048-60. DOI: 10.1101/gad.11.8.1048. View

Kitagawa K, Shibata K, Matsumoto A, Matsumoto M, Ohhata T, Nakayama K . Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development. Mol Cell Biol. 2014; 34(14):2732-44. PMC: 4097664. DOI: 10.1128/MCB.01549-13. View

10.

Stankiewicz M, Crispino J . AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL. Leukemia. 2013; 27(6):1339-47. PMC: 3915509. DOI: 10.1038/leu.2013.33. View

11.

Zhang S, Ma L, Huang Q, Li G, Gu B, Gao X . Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci U S A. 2008; 105(6):2076-81. PMC: 2538883. DOI: 10.1073/pnas.0711824105. View

12.

Groet J, McElwaine S, Spinelli M, Rinaldi A, Burtscher I, Mulligan C . Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Lancet. 2003; 361(9369):1617-20. DOI: 10.1016/S0140-6736(03)13266-7. View

13.

Ho I, Vorhees P, Marin N, Oakley B, Tsai S, Orkin S . Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene. EMBO J. 1991; 10(5):1187-92. PMC: 452772. DOI: 10.1002/j.1460-2075.1991.tb08059.x. View

14.

Fujiwara Y, Browne C, Cunniff K, Goff S, Orkin S . Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci U S A. 1996; 93(22):12355-8. PMC: 37995. DOI: 10.1073/pnas.93.22.12355. View

15.

Rodrigues N, Boyd A, Fugazza C, May G, Guo Y, Tipping A . GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood. 2008; 112(13):4862-73. DOI: 10.1182/blood-2008-01-136564. View

16.

Shih A, Jiang Y, Meydan C, Shank K, Pandey S, Barreyro L . Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia. Cancer Cell. 2015; 27(4):502-15. PMC: 4518555. DOI: 10.1016/j.ccell.2015.03.009. View

17.

Gao X, Sedgwick T, Shi Y, Evans T . Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol. 1998; 18(5):2901-11. PMC: 110669. DOI: 10.1128/MCB.18.5.2901. View

18.

Fitch S, Kimber G, Wilson N, Parker A, Mirshekar-Syahkal B, Gottgens B . Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Cell Stem Cell. 2012; 11(4):554-66. PMC: 3510442. DOI: 10.1016/j.stem.2012.07.002. View

19.

Chia I, Grote D, Marcotte M, Batourina E, Mendelsohn C, Bouchard M . Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development. 2011; 138(10):2089-97. PMC: 3082308. DOI: 10.1242/dev.056838. View

20.

Chia N, Deng N, Das K, Huang D, Hu L, Zhu Y . Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2014; 64(5):707-19. DOI: 10.1136/gutjnl-2013-306596. View