Asians Compared to Whites Show Increased Response to D-amphetamine on Select Subjective and Cardiovascular Measures

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2016 Mar 9

PMID 26952590

Citations 1

Authors

Raina D Pang

Matthew G Kirkpatrick

Nicholas I Goldenson

Casey R Guillot

Adam M Leventhal

Affiliations

Soon will be listed here.

Abstract

Objective: Identifying factors that moderate subjective response to stimulants is important for understanding individuals at risk for abusing these drugs. Some research suggests that Asians may respond differently to stimulants than other races, but controlled human laboratory research of stimulant administration effects in Asians is scant.

Methods: In this double-blind counterbalanced within-subject study, healthy stimulant-naïve participants (N = 65; 55% Asian; 63% female; age 18-35) received a single dose of 20-mg oral d-amphetamine or placebo on separate days. At each testing day, subjective measures of abuse liability and cardiovascular assessments were administered at repeated intervals before and after drug administration over a 4-hour period.

Results: Asians (vs. Whites) demonstrated greater d-amphetamine-induced increases in diastolic blood pressure and ratings of 'Feel High' and 'Like Drug'.

Conclusions: Asian and White healthy young adults may differ in certain subjective and cardiovascular responses to acute doses of d-amphetamine. Such individual differences could help explain between-person differences in abuse potential of d-amphetamine and other stimulants.

Citing Articles

Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults.

Leventhal A, Kirkpatrick M, Pester M, McGeary J, Swift R, Sussman S Psychopharmacology (Berl). 2016; 234(2):307-315.

PMID: 27771748 DOI: 10.1007/s00213-016-4462-z.

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