Pulmonary Function Tests in Sickle Cell Disease

Overview

Journal Indian J Pediatr

Specialty Pediatrics

Date 2016 Mar 6

PMID 26944430

Citations 2

Authors

Raviraj Purohit

Sanjeev S Rao

Jagdish P Goyal

Vijay B Shah

Jaykaran Charan

Affiliations

Soon will be listed here.

Abstract

Objective: To determine pulmonary function abnormalities in children with Sickle Cell Disease (SCD) from Western India.

Methods: In this cross sectional study conducted at Surat, Gujarat, India; equal number of age and gender matched children i.e., 99 in the age group of 6-18 y was recruited in case (children with SCD) and control (non-SCD healthy children) groups respectively. Weight, height, body mass index (BMI) and hemoglobin (Hb) were assessed as baseline characteristics and spirometry was performed to assess the pulmonary function.

Results: The two groups of children were comparable in the baseline characteristics such as weight, height and BMI, however mean hemoglobin was significantly low in SCD as compared to healthy controls [9.1 ± 1.52 vs. 11.4 ± 1.04 (p=0.001)]. Mean (% predicted) Forced expiratory volume in 1 s (FEV1) (86.79 ± 11.6 vs. 94.3 ± 16.1) and FVC (84.4 ± 11.5 vs. 91.75 ± 15.2) values were significantly low (p < 0.001) in cases.

Conclusions: The present study revealed that the difference of pulmonary function tests between sickle cell patients and normal age matched controls were statistically significant but this difference was not clinically significant.

Citing Articles

Pulmonary Function Test Abnormalities in Children with Sickle Cell Anemia: A Cross-Sectional Study from a Tertiary Care Centre in Odisha, India.

Sahu S, Behera M, Gannavarapu N, Das P, Mohapatra A, Mohakud A Cureus. 2025; 17(1):e77977.

PMID: 39996175 PMC: 11849798. DOI: 10.7759/cureus.77977.

Variation in pulmonary function tests among children with sickle cell anemia: a systematic review and meta-analysis.

Taksande A, Zeeshan Jameel P, Pujari D, Taksande B, Meshram R Pan Afr Med J. 2021; 39:140.

PMID: 34527156 PMC: 8418170. DOI: 10.11604/pamj.2021.39.140.28755.

Correlates of Pulmonary Function in Children with Sickle Cell Disease and Elevated Fetal Hemoglobin.

Adekile A, Azab A, Owayed A, Khadadah M Med Princ Pract. 2017; 27(1):49-54.

PMID: 29183008 PMC: 5968263. DOI: 10.1159/000485801.

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