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Long Noncoding RNAs in Regulating Adipogenesis: New RNAs Shed Lights on Obesity

Overview
Publisher Springer
Specialty Biology
Date 2016 Mar 5
PMID 26943803
Citations 61
Authors
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Abstract

Long noncoding RNAs (lncRNAs) are an emerging class of regulators involved in a myriad of biological processes. Recent studies have revealed that many lncRNAs play pivotal roles in regulating adipocyte development. Due to the prevalence of obesity and the serious effects of adiposity on human health and society development, it is necessary to summarize functions and recent advances of lncRNAs in adipogenesis. In this review, we highlight functional lncRNAs contributed to the regulation of adipogenesis, discussing their potential use as therapeutic targets to combat human obesity.

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References
1.
Wapinski O, Chang H . Long noncoding RNAs and human disease. Trends Cell Biol. 2011; 21(6):354-61. DOI: 10.1016/j.tcb.2011.04.001. View

2.
Xiao T, Liu L, Li H, Sun Y, Luo H, Li T . Long Noncoding RNA ADINR Regulates Adipogenesis by Transcriptionally Activating C/EBPα. Stem Cell Reports. 2015; 5(5):856-865. PMC: 4649137. DOI: 10.1016/j.stemcr.2015.09.007. View

3.
Cannon B, Nedergaard J . Brown adipose tissue: function and physiological significance. Physiol Rev. 2004; 84(1):277-359. DOI: 10.1152/physrev.00015.2003. View

4.
Novikova I, Hennelly S, Sanbonmatsu K . Sizing up long non-coding RNAs: do lncRNAs have secondary and tertiary structure?. Bioarchitecture. 2012; 2(6):189-99. PMC: 3527312. DOI: 10.4161/bioa.22592. View

5.
Rajakumari S, Wu J, Ishibashi J, Lim H, Giang A, Won K . EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013; 17(4):562-74. PMC: 3622114. DOI: 10.1016/j.cmet.2013.01.015. View