Malignant Phyllodes Tumor Metastasized to the Right Ventricle: a Case Report

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2016 Mar 5

PMID 26943445

Citations 7

Authors

Fumi Yoshidaya

Naoki Hayashi

Katsuhito Takahashi

Koyu Suzuki

Futoshi Akiyama

Mitsutomi Ishiyama

Yuko Takahashi

Atsushi Yoshida

Hiroshi Yagata

Seigo Nakamura

Hiroko Tsunoda

Hideko Yamauchi

Affiliations

Soon will be listed here.

Abstract

Cardiac metastasis of malignant phyllodes tumor is very rare. We herein report a rare case that developed cardiac metastasis from malignant phyllodes tumor. A 38-year-old woman underwent lumpectomy, and the final pathological findings showed the 5-cm malignant phyllodes tumor partially containing 1 cm of squamous cell carcinoma. Four months after the first surgery, a local recurrence of malignant phyllodes tumor and distant metastases to the bone, lung, pulmonary main trunk, and right ventricle were detected. Mass reduction surgery of cardiac metastasis of the malignant phyllodes tumor was performed to avoid sudden death. In immunohistochemical findings, the tumor was suspected to be originated in myoepithelial cells because of the expression of smooth muscle lineage including α-smooth muscle actin and Calponin1 and highly malignant characteristics showing MIB-1 and p53 highly positive with angiogenesis. Further studies are needed to clarify the effective treatment to these tumors.

Citing Articles

Unusual Metastatic Sites in Malignant Phyllodes Tumor Detected on FDG PET/CT.

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Management and Outcomes of Metastatic and Recurrent Malignant Phyllodes Tumors of the Breast: A Systematic Literature Review.

Samii E, Hurni Y, Huber D Eur J Breast Health. 2023; 19(3):191-200.

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Malignant phyllodes tumor of the breast with metastases to the lungs: A case report and literature review.

Ostapenko E, Burneckis A, Ostapenko A, Skaisgiryte A, Ostapenko V Radiol Case Rep. 2022; 17(10):4006-4012.

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Case Report: Mitral valve obstruction by metastatic malignant phyllodes tumor.

Ikram C, Nesrine A, Rania K, Bellalah A, Chokri K, Asma A F1000Res. 2022; 11:309.

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Abe H, Teramoto A, Takei Y, Tanaka Y, Yoneda G Surg Case Rep. 2020; 6(1):308.

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