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The Thyroid Hormone Triiodothyronine Reinvigorates Dendritic Cells and Potentiates Anti-tumor Immunity

Overview
Journal Oncoimmunology
Specialty Allergy & Immunology
Date 2016 Mar 5
PMID 26942081
Citations 7
Authors
V A Alamino
M M Montesinos
G A Rabinovich
C G Pellizas
Affiliations
Soon will be listed here.
Abstract

Dendritic cell (DC) cancer vaccines have shown limited clinical benefit. Thus, the identification of signals and molecular pathways that potentiate the immunogenicity of DCs has become a major challenge in cancer research. Our studies demonstrate that triiodothyronine endows DCs with enhanced ability to stimulate cytotoxic T-cell responses with implications in DC-based immunotherapy.

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