Peptidylarginine Deiminases As Drug Targets in Neonatal Hypoxic-Ischemic Encephalopathy

Overview

Journal Front Neurol

Specialty Neurology

Date 2016 Mar 5

PMID 26941709

Citations 17

Authors

Sigrun Lange

Affiliations

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Abstract

Oxygen deprivation and infection are major causes of perinatal brain injury leading to cerebral palsy and other neurological disabilities. The identification of novel key factors mediating white and gray matter damage are crucial to allow better understanding of the specific contribution of different cell types to the injury processes and pathways for clinical intervention. Recent studies in the Rice-Vannucci mouse model of neonatal hypoxic ischemia (HI) have highlighted novel roles for calcium-regulated peptidylarginine deiminases (PADs) and demonstrated neuroprotective effects of pharmacological PAD inhibition following HI and synergistic infection mimicked by lipopolysaccharide stimulation.

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