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Current Issues in the Diagnosis and Treatment of Endometrial Carcinoma

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Date 2016 Mar 5
PMID 26941450
Citations 11
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Abstract

Endometrial carcinoma is the most common carcinoma of the female genital tract. Its most important clinical sign is postmenopausal bleeding. An endometrial biopsy is essential for diagnosis. Treatment decisions are governed by tumour risk assessment and patient comorbidity, which is often present. Pelvic and paraaortic lymph node dissection is unnecessary in low risk cases (definition: pT1 a, G1/2) and adjuvant radiotherapy and systemic treatments are usually avoidable. Treatment of high-risk patients (G3 and/or pT1b) and palliative cases is difficult and not well standardised. New molecular-based subtype classification may help treatment decision making in future.

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References
1.
Kitchener H, Swart A, Qian Q, Amos C, Parmar M . Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet. 2008; 373(9658):125-36. PMC: 2646126. DOI: 10.1016/S0140-6736(08)61766-3. View

2.
Benedetti Panici P, Basile S, Maneschi F, Lissoni A, Signorelli M, Scambia G . Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst. 2008; 100(23):1707-16. DOI: 10.1093/jnci/djn397. View

3.
Zuber T . Endometrial biopsy. Am Fam Physician. 2001; 63(6):1131-5, 1137-41. View

4.
Jacobs I, Gentry-Maharaj A, Burnell M, Manchanda R, Singh N, Sharma A . Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncol. 2010; 12(1):38-48. DOI: 10.1016/S1470-2045(10)70268-0. View

5.
Gallos I, Yap J, Rajkhowa M, Luesley D, Coomarasamy A, Gupta J . Regression, relapse, and live birth rates with fertility-sparing therapy for endometrial cancer and atypical complex endometrial hyperplasia: a systematic review and metaanalysis. Am J Obstet Gynecol. 2012; 207(4):266.e1-12. DOI: 10.1016/j.ajog.2012.08.011. View