Visual Assessment of Biliary Excretion of Gd-EOB-DTPA in Patients with Suspected Diffuse Liver Disease - A Biopsy-verified Prospective Study

Overview

Journal Eur J Radiol Open

Specialty Radiology

Date 2016 Mar 4

PMID 26937432

Citations 5

Authors

Bengt Noren

Nils Dahlstrom

Mikael Fredrik Forsgren

Olof Dahlqvist Leinhard

Stergios Kechagias

Sven Almer

Staffan Wirell

Orjan Smedby

Peter Lundberg

Affiliations

Soon will be listed here.

Abstract

Objectives: To qualitatively evaluate late dynamic contrast phases, 10, 20 and 30 min, after administration of Gd-EOB-DTPA with regard to biliary excretion in patients presenting with elevated liver enzymes without clinical signs of cirrhosis or hepatic decompensation and to compare the visual assessment of contrast agent excretion with histo-pathological fibrosis stage, contrast uptake parameters and blood tests.

Methods: 29 patients were prospectively examined using 1.5 T MRI. The visually assessed presence or absence of contrast agent for each of five anatomical regions in randomly reviewed time-series was summarized on a four grade scale for each patient. The scores, including a total visual score, were related to the histo-pathological findings, the quantitative contrast agent uptake parameters, expressed as K Hep or LSC_N, and blood tests.

Results: No relationship between the fibrosis grade or contrast uptake parameters could be established. A negative correlation between the visual assessment and alkaline phosphatase (ALP) was found. Comparing a sub-group of cholestatic patients with fibrosis score and Gd-EOB-DTPA dynamic parameters did not add any additional significant correlation.

Conclusions: No correlation between visually assessed biliary excretion of Gd-EOB-DTPA and histo-pathological or contrast uptake parameters was found. A negative correlation between the visual assessment and alkaline phosphatase (ALP) was found.

Citing Articles

Primary Sclerosing Cholangitis: Diagnostic Criteria.

Cazzagon N, Sarcognato S, Catanzaro E, Bonaiuto E, Peviani M, Pezzato F Tomography. 2024; 10(1):47-65.

PMID: 38250951 PMC: 10820917. DOI: 10.3390/tomography10010005.

Liver-spleen contrast standardization of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging based on cross-calibration.

Mori H, Akimoto S Quant Imaging Med Surg. 2022; 12(12):5343-5357.

PMID: 36465824 PMC: 9703119. DOI: 10.21037/qims-22-174.

Hepatocellular carcinoma grading and recurrence prediction using T mapping on gadolinium-ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging.

Qin X, Yang T, Huang Z, Long L, Zhou Z, Li W Oncol Lett. 2019; 18(3):2322-2329.

PMID: 31404322 PMC: 6676719. DOI: 10.3892/ol.2019.10557.

Gd-EOB-DTP-enhanced MRC in the preoperative percutaneous management of intra and extrahepatic biliary leakages: does it matter?.

Petrillo M, Ierardi A, Tofanelli L, Maresca D, Angileri A, Patella F Gland Surg. 2019; 8(2):174-183.

PMID: 31183327 PMC: 6534763. DOI: 10.21037/gs.2019.03.09.

Magnetic resonance elastography in a rabbit model of liver fibrosis: a 3-T longitudinal validation for clinical translation.

Zou L, Jiang J, Zhong W, Wang C, Xing W, Zhang Z Am J Transl Res. 2016; 8(11):4922-4931.

PMID: 27904692 PMC: 5126334.

References

Noren B, Forsgren M, Dahlqvist Leinhard O, Dahlstrom N, Kihlberg J, Romu T . Separation of advanced from mild hepatic fibrosis by quantification of the hepatobiliary uptake of Gd-EOB-DTPA. Eur Radiol. 2012; 23(1):174-81. DOI: 10.1007/s00330-012-2583-2. View

Watanabe H, Kanematsu M, Goshima S, Kondo H, Onozuka M, Moriyama N . Staging hepatic fibrosis: comparison of gadoxetate disodium-enhanced and diffusion-weighted MR imaging--preliminary observations. Radiology. 2011; 259(1):142-50. DOI: 10.1148/radiol.10100621. View

Chen B, Hsu C, Yu C, Wei S, Kao J, Lee H . Dynamic contrast-enhanced magnetic resonance imaging with Gd-EOB-DTPA for the evaluation of liver fibrosis in chronic hepatitis patients. Eur Radiol. 2011; 22(1):171-80. DOI: 10.1007/s00330-011-2249-5. View

Ryeom H, Kim S, Kim J, Kim H, Lee J, Chang Y . Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol. 2005; 5(4):231-9. PMC: 2698167. DOI: 10.3348/kjr.2004.5.4.231. View

Tamada T, Ito K, Sone T, Kanki A, Sato T, Higashi H . Gd-EOB-DTPA enhanced MR imaging: evaluation of biliary and renal excretion in normal and cirrhotic livers. Eur J Radiol. 2010; 80(3):e207-11. DOI: 10.1016/j.ejrad.2010.08.033. View

Dahlqvist Leinhard O, Dahlstrom N, Kihlberg J, Sandstrom P, Brismar T, Smedby O . Quantifying differences in hepatic uptake of the liver specific contrast agents Gd-EOB-DTPA and Gd-BOPTA: a pilot study. Eur Radiol. 2011; 22(3):642-53. DOI: 10.1007/s00330-011-2302-4. View

Muller M, Jansen P . Molecular aspects of hepatobiliary transport. Am J Physiol. 1997; 272(6 Pt 1):G1285-303. DOI: 10.1152/ajpgi.1997.272.6.G1285. View

Kullak-Ublick G, Baretton G, Oswald M, Renner E, Paumgartner G, Beuers U . Expression of the hepatocyte canalicular multidrug resistance protein (MRP2) in primary biliary cirrhosis. Hepatol Res. 2002; 23(1):78-82. DOI: 10.1016/s1386-6346(01)00159-0. View

Yamada A, Hara T, Li F, Fujinaga Y, Ueda K, Kadoya M . Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging. Radiology. 2011; 260(3):727-33. DOI: 10.1148/radiol.11100586. View

10.

Rydell J, Knutsson H, Pettersson J, Johansson A, Farneback G, Dahlqvist O . Phase sensitive reconstruction for water/fat separation in MR imaging using inverse gradient. Med Image Comput Comput Assist Interv. 2007; 10(Pt 1):210-8. DOI: 10.1007/978-3-540-75757-3_26. View

11.

Trauner M, Boyer J . Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 2003; 83(2):633-71. DOI: 10.1152/physrev.00027.2002. View

12.

Zollner G, Trauner M . Mechanisms of cholestasis. Clin Liver Dis. 2008; 12(1):1-26, vii. DOI: 10.1016/j.cld.2007.11.010. View

13.

Motosugi U, Ichikawa T, Sou H, Sano K, Tominaga L, Kitamura T . Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement?. J Magn Reson Imaging. 2009; 30(5):1042-6. DOI: 10.1002/jmri.21956. View

14.

Tschirch F, Struwe A, Petrowsky H, Kakales I, Marincek B, Weishaupt D . Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma. Eur Radiol. 2008; 18(8):1577-86. DOI: 10.1007/s00330-008-0929-6. View

15.

Batts K, Ludwig J . Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol. 1995; 19(12):1409-17. DOI: 10.1097/00000478-199512000-00007. View

16.

Van Beers B, Pastor C, Hussain H . Primovist, Eovist: what to expect?. J Hepatol. 2012; 57(2):421-9. DOI: 10.1016/j.jhep.2012.01.031. View

17.

Tsuda N, Okada M, Murakami T . New proposal for the staging of nonalcoholic steatohepatitis: evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI. Eur J Radiol. 2008; 73(1):137-42. DOI: 10.1016/j.ejrad.2008.09.036. View