» Articles » PMID: 26937275

Early Lessons from Schistosomiasis Mass Drug Administration Programs

Overview
Journal F1000Res
Date 2016 Mar 4
PMID 26937275
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

Mass drug administration using praziquantel is the backbone of the current strategy for the control of schistosomiasis. As the theoretical plans have moved into practical application, certain challenges with this approach have surfaced, and it is likely that annual mass drug administration alone may not be sufficient to achieve program goals. However, mass drug administration is still the only available intervention that can be readily used in the wide variety of settings where schistosomiasis is endemic. The task then becomes how to improve this approach and identify what adjuncts to mass drug administration are effective, as programs move from morbidity control to elimination goals. Other aspects worthy of consideration include how best to employ new diagnostic tools to more easily identify where treatment is needed, and new formulations of praziquantel to extend the availability of treatment to all age groups. The aim of this review is to highlight both areas of challenge and of opportunity to improve the public health impact of schistosomiasis control programs.

Citing Articles

The Prevalence of and Its Impact on the Hematological Profile of Children Living in Northern Madagascar.

Wilczynska W, Kasprowicz D, Swietlik D, Korzeniewski K Pathogens. 2025; 14(2).

PMID: 40005547 PMC: 11858103. DOI: 10.3390/pathogens14020172.


Optimized strategy for schistosomiasis elimination: results from marginal benefit modeling.

Li Q, Zheng J, Jia T, Feng X, Lv C, Zhang L Parasit Vectors. 2023; 16(1):419.

PMID: 37968661 PMC: 10652544. DOI: 10.1186/s13071-023-06001-x.


Improving the Response of Health Systems to Female Genital Schistosomiasis in Endemic Countries through a Gender-Sensitive Human Rights-Based Framework.

Vlassoff C, Arogundade K, Patel K, Jacobson J, Gyapong M, Krentel A Diseases. 2022; 10(4).

PMID: 36547211 PMC: 9777435. DOI: 10.3390/diseases10040125.


Short-, Mid-, and Long-Term Epidemiological and Economic Effects of the World Bank Loan Project on Schistosomiasis Control in the People's Republic of China.

Li Q, Xu J, Li S, Utzinger J, McManus D, Zhou X Diseases. 2022; 10(4).

PMID: 36278583 PMC: 9624324. DOI: 10.3390/diseases10040084.


Estimating the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers keeping cattle, sheep and goats in northern Senegal.

Adeyemo P, Leger E, Hollenberg E, Diouf N, Sene M, Webster J Parasit Vectors. 2022; 15(1):101.

PMID: 35317827 PMC: 8938966. DOI: 10.1186/s13071-021-05147-w.


References
1.
Jothikumar N, Mull B, Brant S, Loker E, Collinson J, Evan Secor W . Real-time PCR and sequencing assays for rapid detection and identification of avian schistosomes in environmental samples. Appl Environ Microbiol. 2015; 81(12):4207-15. PMC: 4524150. DOI: 10.1128/AEM.00750-15. View

2.
Tchuente L, Kuete Fouodo C, Ngassam R, Sumo L, Dongmo Noumedem C, Kenfack C . Evaluation of circulating cathodic antigen (CCA) urine-tests for diagnosis of Schistosoma mansoni infection in Cameroon. PLoS Negl Trop Dis. 2012; 6(7):e1758. PMC: 3409114. DOI: 10.1371/journal.pntd.0001758. View

3.
Mwinzi P, Kittur N, Ochola E, Cooper P, Campbell Jr C, King C . Additional Evaluation of the Point-of-Contact Circulating Cathodic Antigen Assay for Schistosoma mansoni Infection. Front Public Health. 2015; 3:48. PMC: 4365547. DOI: 10.3389/fpubh.2015.00048. View

4.
Won K, Abudho B, Blackstock A, Montgomery S, Kennedy E, Person B . Assessment of quality of life as a tool for measuring morbidity due to Schistosoma mansoni infection and the impact of treatment. Am J Trop Med Hyg. 2013; 90(2):322-8. PMC: 3919242. DOI: 10.4269/ajtmh.13-0361. View

5.
Stothard J, Sousa-Figueiredo J, Betson M, Bustinduy A, Reinhard-Rupp J . Schistosomiasis in African infants and preschool children: let them now be treated!. Trends Parasitol. 2013; 29(4):197-205. PMC: 3878762. DOI: 10.1016/j.pt.2013.02.001. View