Regulation of Th2 Cell Immunity by Dendritic Cells

Overview

Journal Immune Netw

Specialty Allergy & Immunology

Date 2016 Mar 4

PMID 26937227

Citations 40

Authors

Hyeongjin Na

Minkyoung Cho

Yeonseok Chung

Affiliations

Soon will be listed here.

Abstract

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.

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References

Loke P, Allison J . PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci U S A. 2003; 100(9):5336-41. PMC: 154346. DOI: 10.1073/pnas.0931259100. View

Ito T, Wang Y, Duramad O, Hori T, Delespesse G, Watanabe N . TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med. 2005; 202(9):1213-23. PMC: 2213234. DOI: 10.1084/jem.20051135. View

Perrigoue J, Saenz S, Siracusa M, Allenspach E, Taylor B, Giacomin P . MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol. 2009; 10(7):697-705. PMC: 2711559. DOI: 10.1038/ni.1740. View

Halim T, Hwang Y, Scanlon S, Zaghouani H, Garbi N, Fallon P . Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses. Nat Immunol. 2015; 17(1):57-64. PMC: 4685755. DOI: 10.1038/ni.3294. View

Liu Z, Song J, Liu X, Jiang J, Chen X, Yang L . Mast cell-derived serine proteinase regulates T helper 2 polarization. Sci Rep. 2014; 4:4649. PMC: 3983597. DOI: 10.1038/srep04649. View

Caruso R, Sarra M, Stolfi C, Rizzo A, Fina D, Fantini M . Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut. Gastroenterology. 2009; 136(7):2270-9. DOI: 10.1053/j.gastro.2009.02.049. View

Kumamoto Y, Linehan M, Weinstein J, Laidlaw B, Craft J, Iwasaki A . CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity. 2013; 39(4):733-43. PMC: 3819035. DOI: 10.1016/j.immuni.2013.08.029. View

Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T . A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One. 2013; 8(9):e73270. PMC: 3767795. DOI: 10.1371/journal.pone.0073270. View

Steinfelder S, Andersen J, Cannons J, Feng C, Joshi M, Dwyer D . The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J Exp Med. 2009; 206(8):1681-90. PMC: 2722182. DOI: 10.1084/jem.20082462. View

10.

Nakanishi K . Basophils as APC in Th2 response in allergic inflammation and parasite infection. Curr Opin Immunol. 2010; 22(6):814-20. DOI: 10.1016/j.coi.2010.10.018. View

11.

Fukuoka A, Futatsugi-Yumikura S, Takahashi S, Kazama H, Iyoda T, Yoshimoto T . Identification of a novel type 2 innate immunocyte with the ability to enhance IgE production. Int Immunol. 2013; 25(6):373-82. DOI: 10.1093/intimm/dxs160. View

12.

Raymond M, Rubio M, Fortin G, Shalaby K, Hammad H, Lambrecht B . Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation. J Allergy Clin Immunol. 2009; 124(6):1333-42.e1. DOI: 10.1016/j.jaci.2009.07.021. View

13.

Al-Shami A, Spolski R, Kelly J, Keane-Myers A, Leonard W . A role for TSLP in the development of inflammation in an asthma model. J Exp Med. 2005; 202(6):829-39. PMC: 2212950. DOI: 10.1084/jem.20050199. View

14.

Sato K, Imai Y, Irimura T . Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity. J Immunol. 1998; 161(12):6835-44. View

15.

Schlitzer A, McGovern N, Teo P, Zelante T, Atarashi K, Low D . IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity. 2013; 38(5):970-83. PMC: 3666057. DOI: 10.1016/j.immuni.2013.04.011. View

16.

Eisenbarth S, Piggott D, Huleatt J, Visintin I, Herrick C, Bottomly K . Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med. 2002; 196(12):1645-51. PMC: 2196061. DOI: 10.1084/jem.20021340. View

17.

Everts B, Hussaarts L, Driessen N, Meevissen M, Schramm G, van der Ham A . Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor. J Exp Med. 2012; 209(10):1753-67, S1. PMC: 3457738. DOI: 10.1084/jem.20111381. View

18.

Yang D, Postnikov Y, Li Y, Tewary P, de la Rosa G, Wei F . High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses. J Exp Med. 2011; 209(1):157-71. PMC: 3260868. DOI: 10.1084/jem.20101354. View

19.

Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick J, Tsai M . Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol. 2006; 176(4):2238-48. DOI: 10.4049/jimmunol.176.4.2238. View

20.

Williams J, Tjota M, Clay B, Vander Lugt B, Bandukwala H, Hrusch C . Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun. 2013; 4:2990. PMC: 4003872. DOI: 10.1038/ncomms3990. View