Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories

Overview

Journal Neural Plast

Specialty Neurology

Date 2016 Mar 3

PMID 26933513

Citations 11

Authors

Ossama Khalaf

Johannes Graff

Affiliations

Soon will be listed here.

Abstract

Our memories are the records of the experiences we gain in our everyday life. Over time, they slowly transform from an initially unstable state into a long-lasting form. Many studies have been investigating from different aspects how a memory could persist for sometimes up to decades. In this review, we highlight three of the greatly addressed mechanisms that play a central role for a given memory to endure: the allocation of the memory to a given neuronal population and what brain areas are recruited for its storage; the structural changes that underlie memory persistence; and finally the epigenetic control of gene expression that might regulate and support memory perseverance. Examining such key properties of a memory is essential towards a finer understanding of its capacity to last.

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