A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

Overview

Journal J Maxillofac Oral Surg

Date 2016 Mar 2

PMID 26929560

Citations 6

Authors

M Shyamala

C Ramesh

V Yuvaraj

V Suresh

R Sathyanarayanan

T S Balaji

M Neil Dominic

B Nithin Joseph Jude

Affiliations

Soon will be listed here.

Abstract

Objectives: To compare the effectiveness of bupivacaine with adrenaline with that of carbonated bupivacaine with adrenaline on pain, onset of anesthesia and duration of anesthesia following surgical removal of impacted mandibular third molar.

Study Design: All the patients who underwent surgical removal of impacted mandibular third molar and who fulfilled our inclusion and exclusion criteria from 1st June 2013 to 30th June 2014 were included in our study. Patients who were diagnosed as having impacted mandibular third molar were randomly allocated to two groups namely group A (bupivacaine with adrenaline), group B (carbonated bupivacaine with adrenaline). Pain during deposition of local anesthetic, onset of anesthesia and duration of anesthesia were compared between the two groups. The collected data were subjected to statistical analysis by Chi Square test, Mann-Whitney U test.

Results And Conclusion: The efficacy of carbonated bupivacaine with adrenaline is more compared with bupivacaine with adrenaline in decreasing pain on deposition of local anesthetic solution and in rapid onset of anesthesia. The duration of anesthesia for carbonated bupivacaine with adrenaline and bupivacaine with adrenaline had no significant difference. The use of carbonated bupivacaine with adrenaline will reduce the patient discomfort both intra-operatively and post-operatively.

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References

Bouloux G . Bupivacaine versus lidocaine for third molar surgery: a double-blind, randomized, crossover study. J Oral Maxillofac Surg. 1999; 57(5):510-4; discussion 515. DOI: 10.1016/s0278-2391(99)90063-0. View

Younessi O . Cardiovascular effects of bupivacaine and the role of this agent in preemptive dental analgesia. Anesth Prog. 2000; 46(2):56-62. PMC: 2148896. View

Fulling P, Peterfreund R . Alkalinization and precipitation characteristics of 0.2% ropivacaine. Reg Anesth Pain Med. 2000; 25(5):518-21. DOI: 10.1053/rapm.2000.8931. View

Obiechina A, Arotiba J, Fasola A . Third molar impaction: evaluation of the symptoms and pattern of impaction of mandibular third molar teeth in Nigerians. Odontostomatol Trop. 2001; 24(93):22-5. View

Sisk A . Long-acting local anesthetics in dentistry. Anesth Prog. 1992; 39(3):53-60. PMC: 2148750. View

Ong K, Seymour R, Chen F, Ho V . Preoperative ketorolac has a preemptive effect for postoperative third molar surgical pain. Int J Oral Maxillofac Surg. 2004; 33(8):771-6. DOI: 10.1016/j.ijom.2004.01.020. View

Rosenberg P, Veering B, Urmey W . Maximum recommended doses of local anesthetics: a multifactorial concept. Reg Anesth Pain Med. 2005; 29(6):564-75. DOI: 10.1016/j.rapm.2004.08.003. View

Niemi G . Advantages and disadvantages of adrenaline in regional anaesthesia. Best Pract Res Clin Anaesthesiol. 2005; 19(2):229-45. DOI: 10.1016/j.bpa.2004.12.004. View

Fernandez C, Reader A, Beck M, Nusstein J . A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for inferior alveolar nerve blocks. J Endod. 2005; 31(7):499-503. DOI: 10.1097/01.don.0000167395.61075.38. View

10.

Jung Y, Kim M, Um Y, Park H, Lee E, Kang J . The effects on postoperative oral surgery pain by varying NSAID administration times: comparison on effect of preemptive analgesia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 100(5):559-63. DOI: 10.1016/j.tripleo.2005.02.065. View

11.

Ozer H, Solak S, Oguz T, Ocguder A, Colakoglu T, Babacan A . Alkalinisation of local anaesthetics prescribed for pain relief after surgical decompression of carpal tunnel syndrome. J Orthop Surg (Hong Kong). 2005; 13(3):285-9. DOI: 10.1177/230949900501300312. View

12.

Nayyar M, Yates C . Bupivacaine as pre-emptive analgesia in third molar surgery: Randomised controlled trial. Br J Oral Maxillofac Surg. 2006; 44(6):501-3. DOI: 10.1016/j.bjoms.2005.09.012. View

13.

Volpato M, Ranali J, Ramacciato J, de Oliveira P, Ambrosano G, Groppo F . Anesthetic efficacy of bupivacaine solutions in inferior alveolar nerve block. Anesth Prog. 2006; 52(4):132-5. PMC: 1586800. DOI: 10.2344/0003-3006(2005)52[132:AEB]2.0.CO;2. View

14.

Gordon S, Chuang B, Wang X, Hamza M, Rowan J, Brahim J . The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008; 106(1):321-7, table of contents. DOI: 10.1213/01.ane.0000296474.79437.23. View

15.

Trullenque-Eriksson A, Guisado-Moya B . Comparative study of two local anesthetics in the surgical extraction of mandibular third molars: bupivacaine and articaine. Med Oral Patol Oral Cir Bucal. 2011; 16(3):e390-6. DOI: 10.4317/medoral.16.e390. View

16.

Kashyap V, Desai R, Reddy P, Menon S . Effect of alkalinisation of lignocaine for intraoral nerve block on pain during injection, and speed of onset of anaesthesia. Br J Oral Maxillofac Surg. 2011; 49(8):e72-5. DOI: 10.1016/j.bjoms.2011.04.068. View

17.

Sancho-Puchades M, Vilchez-Perez M, Valmaseda-Castellon E, Paredes-Garcia J, Berini-Aytes L, Gay-Escoda C . Bupivacaine 0.5% versus articaine 4% for the removal of lower third molars. A crossover randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2011; 17(3):e462-8. PMC: 3476102. DOI: 10.4317/medoral.17628. View

18.

Silva L, Santos T, Santos J, Maia M, Mendonca C . Articaine versus lidocaine for third molar surgery: a randomized clinical study. Med Oral Patol Oral Cir Bucal. 2011; 17(1):e140-5. PMC: 3448204. DOI: 10.4317/medoral.17148. View

19.

Niklasson B, Borjesson A, Carmnes U, Segerdahl M, Ohman S, Blanck A . Intraoperative injection of bupivacaine-adrenaline close to the fascia reduces morphine requirements after cesarean section: a randomized controlled trial. Acta Obstet Gynecol Scand. 2012; 91(12):1433-9. DOI: 10.1111/j.1600-0412.2012.01480.x. View

20.

Katz J, Knarr D, Bridenbaugh P . A double-blind comparison of 0.5% bupivacaine and 0.75% ropivacaine administered epidurally in humans. Reg Anesth. 1990; 15(5):250-2. View