Age-related Changes in Anterior Cingulate Cortex Glutamate in Schizophrenia: A (1)H MRS Study at 7 Tesla

Overview

Journal Schizophr Res

Specialty Psychiatry

Date 2016 Mar 2

PMID 26925800

Citations 43

Authors

Allison S Brandt

Paul G Unschuld

Subechhya Pradhan

Issel Anne L Lim

Gregory Churchill

Ashley D Harris

Jun Hua

Peter B Barker

Christopher A Ross

Peter C M van Zijl

Richard A E Edden

Russell L Margolis

Affiliations

Soon will be listed here.

Abstract

The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.

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