Sertoli Cell-Only Syndrome: Behind the Genetic Scenes

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Mar 1

PMID 26925412

Citations 16

Authors

Katrien Stouffs

Alexander Gheldof

Herman Tournaye

Deborah Vandermaelen

Maryse Bonduelle

Willy Lissens

Sara Seneca

Affiliations

Soon will be listed here.

Abstract

Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on genetic causes. Our results show that, for a large part of the patients (>23% in an unselected group), the sex chromosomes are involved. The majority of patients had a Klinefelter syndrome, followed by patients with Yq microdeletions. Array comparative genomic hybridization in a selected group of "idiopathic patients" showed no known infertility related copy number variations.

Citing Articles

Circular RNAs: novel noncoding players in male infertility.

Babakhanzadeh E, Hoseininasab F, Khodadadian A, Nazari M, Hajati R, Ghafouri-Fard S Hereditas. 2024; 161(1):46.

PMID: 39551760 PMC: 11572108. DOI: 10.1186/s41065-024-00346-8.

Semen uric acid crystals in azoospermia linked to Sertoli cell‑only syndrome: A rare case report.

Hama Rashid A, Salih R, Fakhralddin S, Mohammed A, Muhammed H, Ameen Ahmed N Exp Ther Med. 2024; 28(4):397.

PMID: 39171146 PMC: 11336801. DOI: 10.3892/etm.2024.12686.

RNF20 is required for male fertility through regulation of H2B ubiquitination in the Sertoli cells.

Lai F, Wang H, Zhao X, Yang K, Cai L, Hu M Cell Biosci. 2023; 13(1):71.

PMID: 37024990 PMC: 10080854. DOI: 10.1186/s13578-023-01018-2.

Sertoli cell-only syndrome: advances, challenges, and perspectives in genetics and mechanisms.

Wang X, Liu X, Qu M, Li H Cell Mol Life Sci. 2023; 80(3):67.

PMID: 36814036 PMC: 11072804. DOI: 10.1007/s00018-023-04723-w.

Simultaneous Sertoli Cell-Only Syndrome and Leydig Cell Tumor in a Patient with Azoospermia: A Rare Case Report.

Bapir R, Salih R, Salih K, Shabur B, Salih A, Kakamad F Case Rep Oncol. 2023; 15(3):1095-1100.

PMID: 36605229 PMC: 9808302. DOI: 10.1159/000526668.

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