Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling Specificity

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2016 Mar 1

PMID 26925059

Citations 12

Authors

Arkajyoti Mukherjee

Sayoni Roy

Bhaskar Saha

Debasri Mukherjee

Affiliations

Soon will be listed here.

Citing Articles

Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution.

Ong Q, Lim C, Liao Y, Tze-Yang Ng J, Lim L, Yi Koh S bioRxiv. 2025; .

PMID: 39829776 PMC: 11741287. DOI: 10.1101/2025.01.06.631444.

An Update on Protein Kinases as Therapeutic Targets-Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases.

Silnitsky S, Rubin S, Zerihun M, Qvit N Int J Mol Sci. 2023; 24(24).

PMID: 38139428 PMC: 10743896. DOI: 10.3390/ijms242417600.

Dual Regulation of Spine-Specific and Synapse-to-Nucleus Signaling by PKCδ during Plasticity.

Colgan L, Parra-Bueno P, Holman H, Tu X, Jain A, Calubag M J Neurosci. 2023; 43(30):5432-5447.

PMID: 37277178 PMC: 10376934. DOI: 10.1523/JNEUROSCI.0208-22.2023.

Mechanisms Underlying Dichotomous Procoagulant COAT Platelet Generation-A Conceptual Review Summarizing Current Knowledge.

Veuthey L, Aliotta A, Calderara D, Portela C, Alberio L Int J Mol Sci. 2022; 23(5).

PMID: 35269679 PMC: 8910683. DOI: 10.3390/ijms23052536.

Targeted disruption of PKC from AKAP signaling complexes.

Limaye A, Bendzunas G, Kennedy E RSC Chem Biol. 2021; 2(4):1227-1231.

PMID: 34458835 PMC: 8341804. DOI: 10.1039/d1cb00106j.

References

Holm A, Tejle K, Gunnarsson T, Magnusson K, Descoteaux A, Rasmusson B . Role of protein kinase C alpha for uptake of unopsonized prey and phagosomal maturation in macrophages. Biochem Biophys Res Commun. 2003; 302(4):653-8. DOI: 10.1016/s0006-291x(03)00231-6. View

Prekeris R, MAYHEW M, Cooper J, Terrian D . Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol. 1996; 132(1-2):77-90. PMC: 2120693. DOI: 10.1083/jcb.132.1.77. View

Castrillo A, Pennington D, Otto F, Parker P, Owen M, Bosca L . Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med. 2001; 194(9):1231-42. PMC: 2195971. DOI: 10.1084/jem.194.9.1231. View

Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C . PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. PLoS One. 2013; 8(1):e53709. PMC: 3546006. DOI: 10.1371/journal.pone.0053709. View

Sudan R, Srivastava N, Pandey S, Majumdar S, Saha B . Reciprocal regulation of protein kinase C isoforms results in differential cellular responsiveness. J Immunol. 2012; 188(5):2328-37. DOI: 10.4049/jimmunol.1101678. View

Stahelin R, Kong K, Raha S, Tian W, Melowic H, Ward K . Protein kinase Cθ C2 domain is a phosphotyrosine binding module that plays a key role in its activation. J Biol Chem. 2012; 287(36):30518-28. PMC: 3436300. DOI: 10.1074/jbc.M112.391557. View

Das S, Bhattacharjee O, Goswami A, Pal N, Majumdar S . Arabinosylated lipoarabinomannan (Ara-LAM) mediated intracellular mechanisms against tuberculosis infection: involvement of protein kinase C (PKC) mediated signaling. Tuberculosis (Edinb). 2014; 95(2):208-16. DOI: 10.1016/j.tube.2014.11.007. View

Freeley M, Kelleher D, Long A . Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites. Cell Signal. 2010; 23(5):753-62. DOI: 10.1016/j.cellsig.2010.10.013. View

Antal C, Newton A . Tuning the signalling output of protein kinase C. Biochem Soc Trans. 2014; 42(6):1477-83. PMC: 5783555. DOI: 10.1042/BST20140172. View

10.

Holm A , Tejle K, Magnusson K, Descoteaux A, Rasmusson B . Leishmania donovani lipophosphoglycan causes periphagosomal actin accumulation: correlation with impaired translocation of PKCalpha and defective phagosome maturation. Cell Microbiol. 2001; 3(7):439-47. DOI: 10.1046/j.1462-5822.2001.00127.x. View

11.

Bhattacharyya S, Ghosh S, Jhonson P, Bhattacharya S, Majumdar S . Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infect Immun. 2001; 69(3):1499-507. PMC: 98048. DOI: 10.1128/IAI.69.3.1499-1507.2001. View

12.

Dutil E, Keranen L, DePaoli-Roach A, Newton A . In vivo regulation of protein kinase C by trans-phosphorylation followed by autophosphorylation. J Biol Chem. 1994; 269(47):29359-62. View

13.

Steinberg S . Structural basis of protein kinase C isoform function. Physiol Rev. 2008; 88(4):1341-78. PMC: 2899688. DOI: 10.1152/physrev.00034.2007. View

14.

Ron D, Chen C, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D . Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proc Natl Acad Sci U S A. 1994; 91(3):839-43. PMC: 521407. DOI: 10.1073/pnas.91.3.839. View

15.

Marinissen M, Capiati D, Boland R . 1,25(OH)2-vitamin D3 affects the subcellular distribution of protein kinase C isoenzymes in muscle cells. Cell Signal. 1998; 10(2):91-100. DOI: 10.1016/s0898-6568(97)00096-x. View

16.

Bell K, Al-Riyami L, Lumb F, Britton G, Poole A, Williams C . The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62. Immunol Lett. 2015; 168(1):31-40. PMC: 4643489. DOI: 10.1016/j.imlet.2015.09.001. View

17.

Tsai L, Xie L, Dore K, Xie L, Del Rio J, King C . Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015; 290(36):21845-56. PMC: 4571940. DOI: 10.1074/jbc.M115.676221. View

18.

Hoshi N, Langeberg L, Gould C, Newton A, Scott J . Interaction with AKAP79 modifies the cellular pharmacology of PKC. Mol Cell. 2010; 37(4):541-50. PMC: 3014287. DOI: 10.1016/j.molcel.2010.01.014. View

19.

Basu R, Chen Y, Quann E, Huse M . The variable hinge region of novel PKCs determines localization to distinct regions of the immunological synapse. PLoS One. 2014; 9(4):e95531. PMC: 3994095. DOI: 10.1371/journal.pone.0095531. View

20.

Urtreger A, Kazanietz M, Bal de Kier Joffe E . Contribution of individual PKC isoforms to breast cancer progression. IUBMB Life. 2011; 64(1):18-26. DOI: 10.1002/iub.574. View