Laboratory Indicators of Aggrecan Turnover in Juvenile Idiopathic Arthritis

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2016 Mar 1

PMID 26924871

Citations 6

Authors

Katarzyna Winsz-Szczotka

Kornelia Kuznik-Trocha

Katarzyna Komosinska-Vassev

Agnieszka Jura-Poltorak

Krystyna Olczyk

Affiliations

Soon will be listed here.

Abstract

Objectives: Evaluation of chondroitin sulfate (CS), as an early marker of aggrecan degradation, and chondroitin sulfate 846 epitope (CS846), as a biomarker of CS synthesis, is an attempt at answering the question whether the therapy used in juvenile idiopathic arthritis (JIA) patients contributes to the normalization of biochemical changes in aggrecan.

Methods And Results: Serum levels of CS and CS846 as well as catalase (CT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in erythrocyte were assessed in patients before and after treatment. In the course of JIA, aggrecan metabolism is disturbed, which is reflected by a decrease (p < 0.001) in CS serum level and an increase (p < 0.05) in CS846 concentration. Furthermore, increased (p < 0.001) activities of CT, SOD, and GPx in untreated JIA patients were recorded. The anti-inflammatory treatment resulted in the normalization of CS846 level and SOD and GPx activities. In untreated patients, we have revealed a significant correlation between serum CS and CS846, CT, CRP, ESR, MMP-3, and ADAMTS-4, respectively, as well as between CS846 and CT, GPx, CRP, ESR, and TGF-β1, respectively.

Conclusion: The observed changes of CS and CS846 in JIA patients indicate a further need of the therapy continuation aimed at protecting a patient from a possible disability.

Citing Articles

GAAGs, COMP, and YKL-40 as Potential Markers of Cartilage Turnover in Blood of Children with Juvenile Idiopathic Arthritis Treated with Etanercept-Relationship with ADAMTS4, ADAMTS5, and PDGF-BB.

Dabkowska K, Wojdas M, Kuznik-Trocha K, Wisowski G, Gruenpeter A, Komosinska-Vassev K J Clin Med. 2022; 11(17).

PMID: 36079004 PMC: 9457057. DOI: 10.3390/jcm11175069.

The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis.

Kuznik-Trocha K, Winsz-Szczotka K, Lachor-Motyka I, Dabkowska K, Wojdas M, Olczyk K J Clin Med. 2022; 11(7).

PMID: 35407621 PMC: 8999578. DOI: 10.3390/jcm11072013.

Serum lubricin levels in patients with juvenile idiopathic arthritis.

Kisla Ekinci R, Balci S, Coban F, Bisgin A Reumatologia. 2022; 59(6):373-377.

PMID: 35079181 PMC: 8768040. DOI: 10.5114/reum.2021.111696.

Association of Circulating COMP and YKL-40 as Markers of Metabolic Changes of Cartilage with Adipocytokines in Juvenile Idiopathic Arthritis.

Winsz-Szczotka K, Kuznik-Trocha K, Gruenpeter A, Wojdas M, Dabkowska K, Olczyk K Metabolites. 2020; 10(2).

PMID: 32050571 PMC: 7073573. DOI: 10.3390/metabo10020061.

The association of CAT-262C/T polymorphism with catalase activity and treatment response in juvenile idiopathic arthritis.

Basic J, Vojinovic J, Jevtovic-Stoimenov T, Despotovic M, Cvetkovic T, Lazarevic D Rheumatol Int. 2019; 39(3):551-559.

PMID: 30680511 DOI: 10.1007/s00296-019-04246-3.

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