Abdominal Migraine in Children: Association Between Gastric Motility Parameters and Clinical Characteristics

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2016 Mar 1

PMID 26924750

Citations 11

Authors

Niranga Manjuri Devanarayana

Shaman Rajindrajith

Marc A Benninga

Affiliations

Soon will be listed here.

Abstract

Background: Approximately 0.2-1 % of children suffers from abdominal migraine (AM). Pathophysiology of AM has not been adequately studied. This study evaluated gastric motility in children with AM.

Methods: Seventeen children (6 boys), within an age range of 4-15 years, referred to a tertiary care paediatric unit, North Colombo Teaching Hospital Ragama, Sri Lanka, from 2007 to 2012, were screened. Those fulfilling Rome III criteria for AM were recruited after obtaining parental consent. None had clinical or laboratory evidence of organic disorders. Twenty healthy children (8 boys), with an age range of 4-14 years, were recruited as controls. Liquid gastric emptying rate (GE) and antral motility parameters were assessed using an ultrasound method.

Results: Average GE (41.6 % vs. 66.2 %, in controls), amplitude of antral contractions (A) (57.9 % vs. 89.0 %) and antral motility index (MI) (5.0 vs. 8.3) were lower and fasting antral area (1.8 cm(2) vs. 0.6 cm(2)) was higher in children with AM (p < 0.01). No significant difference in the frequency of antral contractions (F) (8.8/3 min vs. 9.3/3 min, p = 0.08) was found between the two groups. Scores obtained for severity of abdominal pain had a negative correlation with A (r = -0.55, p = 0.03). Average duration of abdominal pain episodes correlated with GE (r = -0.58, p = 0.02). Negative correlations were observed between duration of AM and A (r = -0.55), F (r = -0.52), and MI (r = -0.57) (p < 0.05).

Conclusions: GE and antral motility parameters were significantly lower in children with AM. A significant correlation was found between symptoms and gastric motility. These findings suggest a possible role of abnormal gastric motility in the pathogenesis of AM.

Citing Articles

Navigating through 65 years of insights: lessons learned on functional abdominal pain in children.

Rajindrajith S, Boey C, Devanarayana N, Niriella M, Thapar N, Benninga M Eur J Pediatr. 2024; 183(9):3689-3703.

PMID: 38972964 DOI: 10.1007/s00431-024-05667-4.

Abdominal migraine with acute watery diarrhea and dehydration: Successful treatment with Valproic acid in a pediatric case.

Amin M, Manna R, Nahin S, Hawlader M Clin Case Rep. 2024; 12(3):e8703.

PMID: 38523821 PMC: 10957485. DOI: 10.1002/ccr3.8703.

Unraveling Abdominal Migraine in Adults: A Comprehensive Narrative Review.

Kizhakkayil Tency N, Roy A, Krishnakumaran N, Thomas A Cureus. 2023; 15(8):e43760.

PMID: 37727183 PMC: 10506737. DOI: 10.7759/cureus.43760.

Gastric motility and pulmonary function in children with functional abdominal pain disorders and asthma: A pathophysiological study.

Kumari M, Amarasiri L, Rajindrajith S, Devanarayana N PLoS One. 2022; 17(1):e0262086.

PMID: 34982797 PMC: 8726504. DOI: 10.1371/journal.pone.0262086.

Effect of acupuncture at Zusanli (ST36) point on antral contraction function under ultrasound guidance: study protocol of a randomized controlled trial.

Chen Y, Bian Y, Li S, Zhao Y, Li J, Zheng Y Trials. 2021; 22(1):803.

PMID: 34781992 PMC: 8591957. DOI: 10.1186/s13063-021-05704-9.

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