Mutation of is Not a Frequent Occurrence in Prostate Cancer of Korean Patients

Overview

Journal Asian J Androl

Specialty Urology

Date 2016 Mar 1

PMID 26924278

Citations 3

Authors

Nara Yoon

Sharon Lim

So Young Kang

Ghee Young Kwon

Hwang Gyun Jeon

Byong Chang Jeong

Seong Il Seo

Seong Soo Jeon

Hyun Moo Lee

Han Yong Choi

Affiliations

Soon will be listed here.

Abstract

Prostate cancer is one of the major health care problems, but the molecular pathogenesis has been relatively insufficiently elucidated. Recently, whole exome sequencing of prostate cancer identified recurrent mutations involving MED12 in Caucasian patients, which finding was not reproduced in one subsequent study by Sanger sequencing. Thus, we investigated mutation status of MED12 in exons 2 and 26 by Sanger sequencing in 102 radical prostatectomy cases from Korean patients. The analysis found the mutation in none of the cases. Therefore, MED12 mutation does not appear to represent a significant molecular alteration in this cohort of patients according to the analysis by the traditional "gold standard."

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