Pre-transition Effects Mediate Forces of Assembly Between Transmembrane Proteins

Overview

Journal Elife

Specialty Biology

Date 2016 Feb 25

PMID 26910009

Citations 25

Authors

Shachi Katira

Kranthi K Mandadapu

Suriyanarayanan Vaikuntanathan

Berend Smit

David Chandler

Affiliations

Soon will be listed here.

Abstract

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order-disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to this phenomenon as the 'orderphobic effect'. The effect is mediated by proximity to the order-disorder phase transition and the size and hydrophobic mismatch of the protein. The strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.

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