Ketogenic Dietary Therapies in Adults with Epilepsy: a Practical Guide

Overview

Journal Pract Neurol

Specialty Neurology

Date 2016 Feb 25

PMID 26908897

Citations 18

Authors

Natasha E Schoeler

J Helen Cross

Affiliations

Soon will be listed here.

Abstract

Ketogenic dietary therapies are an effective treatment option for children with drug-resistant epilepsy. There is an increasing worldwide interest in using these diets to manage adult epilepsy; uncontrolled studies show similar response rates to those in children. Despite this, there are only a few centres with dedicated services for adults. We clearly need controlled studies of this treatment in adults. Here, we aim to familiarise adult neurologists with the evidence base for these diets and give practical advice on starting and maintaining them in adults.

Citing Articles

The hydroxycarboxylic acid receptor HCA2 is required for the protective effect of ketogenic diet in epilepsy.

Richardson J, Higgins G, Upton N, Massey P, Cunningham M, Wilson S Pharmacol Res Perspect. 2024; 12(6):e70026.

PMID: 39439218 PMC: 11496569. DOI: 10.1002/prp2.70026.

Influence of Carbohydrate Intake on Caprylic Acid (C8:0)-Induced Ketogenesis-A Systematic Review and Meta-Analysis.

Frenser M, Fischer T, Albrecht I, Marquardt T Nutrients. 2024; 16(15).

PMID: 39125337 PMC: 11314469. DOI: 10.3390/nu16152456.

Ketogenic Diets Alter the Gut Microbiome, Resulting in Decreased Susceptibility to and Cognitive Impairment in Rats with Pilocarpine-Induced Status Epilepticus.

Li B, Ma Y, Wang X, Zhao D, Wang Z, Wang G Neurochem Res. 2024; 49(10):2726-2742.

PMID: 38935224 DOI: 10.1007/s11064-024-04168-y.

Tolerance, adherence, and acceptability of a ketogenic 2.5:1 ratio, nutritionally complete, medium chain triglyceride-containing liquid feed in children and adults with drug-resistant epilepsy following a ketogenic diet.

Griffen C, Schoeler N, Browne R, Cameron T, Kirkpatrick M, Thowfeek S Epilepsia Open. 2024; 9(2):727-738.

PMID: 38411329 PMC: 10984290. DOI: 10.1002/epi4.12910.

The ketogenic diet: its impact on human gut microbiota and potential consequent health outcomes: a systematic literature review.

Rew L, Harris M, Goldie J Gastroenterol Hepatol Bed Bench. 2023; 15(4):326-342.

PMID: 36762214 PMC: 9876773. DOI: 10.22037/ghfbb.v15i4.2600.