Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia Among the Population of West Mexico

Overview

Journal Nutrients

Date 2016 Feb 25

PMID 26907331

Citations 35

Authors

Omar Ramos-Lopez

Arturo Panduro

Erika Martinez-Lopez

Sonia Roman

Affiliations

Soon will be listed here.

Abstract

Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders, including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk factor for cardiovascular disease and type 2 diabetes. The sweet taste receptor TAS1R2 polymorphism (Ile191Val) has been reported to be associated with carbohydrate intake. The aim of this study was to analyze the association of the TAS1R2 gene polymorphism with carbohydrate intake and HTG among the population of West Mexico. In a cross-sectional study, 441 unrelated subjects were analyzed for TAS1R2 genotypes (Ile/Ile, Ile/Val and Val/Val) by an allelic discrimination assay. Biochemical tests and a three-day food record were assessed. The Val/Val genotype carriers had a higher intake of total carbohydrates, fiber and servings of cereals and vegetables than the other genotype carriers. The Val/Val genotype conferred a higher risk for HTG than the Ile/Val and Ile/Ile genotypes (OR = 3.26, 95%CI 1.35-7.86, p = 0.006 and OR = 2.61, 95%CI 1.12-6.07, p = 0.02, respectively). Furthermore, the Val/Val genotype was associated with approximately 30% higher triglycerides compared with Ile/Val and Ile/Ile genotypes (β = 44.09, 95%CI 9.94-78.25, p = 0.01 and β = 45.7, 95%CI 10.85-80.54, p = 0.01, respectively). In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.

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References

Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X . Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci U S A. 2004; 101(39):14258-63. PMC: 521102. DOI: 10.1073/pnas.0404384101. View

Tremblay A, Morrissette H, Gagne J, Bergeron J, Gagne C, Couture P . Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population. Clin Biochem. 2004; 37(9):785-90. DOI: 10.1016/j.clinbiochem.2004.03.008. View

Parks E, Krauss R, CHRISTIANSEN M, Neese R, Hellerstein M . Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest. 1999; 104(8):1087-96. PMC: 408572. DOI: 10.1172/JCI6572. View

Bachmanov A, Bosak N, Floriano W, Inoue M, Li X, Lin C . Genetics of sweet taste preferences. Flavour Fragr J. 2011; 26(4):286-294. PMC: 3130742. DOI: 10.1002/ffj.2074. View

Bo S, Cavallo-Perin P, Gentile L, Repetti E, Pagano G . Low HDL-cholesterol: a component of the metabolic syndrome only in the presence of fasting hypertriglyceridemia in type 2 diabetic patients. Diabetes Metab. 2001; 27(1):31-5. View

Roberts R, Bickerton A, Fielding B, Blaak E, Wagenmakers A, Chong M . Reduced oxidation of dietary fat after a short term high-carbohydrate diet. Am J Clin Nutr. 2008; 87(4):824-31. DOI: 10.1093/ajcn/87.4.824. View

Parks E, Hellerstein M . Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr. 2000; 71(2):412-33. DOI: 10.1093/ajcn/71.2.412. View

Rubi-Castellanos R, Martinez-Cortes G, Munoz-Valle J, Gonzalez-Martin A, Cerda-Flores R, Anaya-Palafox M . Pre-Hispanic Mesoamerican demography approximates the present-day ancestry of Mestizos throughout the territory of Mexico. Am J Phys Anthropol. 2009; 139(3):284-94. DOI: 10.1002/ajpa.20980. View

Schwarz J, Linfoot P, Dare D, Aghajanian K . Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets. Am J Clin Nutr. 2002; 77(1):43-50. DOI: 10.1093/ajcn/77.1.43. View

10.

Eny K, Wolever T, Fontaine-Bisson B, El-Sohemy A . Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations. Physiol Genomics. 2008; 33(3):355-60. DOI: 10.1152/physiolgenomics.00148.2007. View

11.

Anderson J . Dietary fiber prevents carbohydrate-induced hypertriglyceridemia. Curr Atheroscler Rep. 2000; 2(6):536-41. DOI: 10.1007/s11883-000-0055-7. View

12.

Roman S, Zepeda-Carrillo E, Moreno-Luna L, Panduro A . Alcoholism and liver disease in Mexico: genetic and environmental factors. World J Gastroenterol. 2013; 19(44):7972-82. PMC: 3848144. DOI: 10.3748/wjg.v19.i44.7972. View

13.

Weissglas-Volkov D, Aguilar-Salinas C, Nikkola E, Deere K, Cruz-Bautista I, Arellano-Campos O . Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. J Med Genet. 2013; 50(5):298-308. PMC: 3917605. DOI: 10.1136/jmedgenet-2012-101461. View

14.

Cui M, Jiang P, Maillet E, Max M, Margolskee R, Osman R . The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des. 2006; 12(35):4591-600. DOI: 10.2174/138161206779010350. View

15.

Fried S, Rao S . Sugars, hypertriglyceridemia, and cardiovascular disease. Am J Clin Nutr. 2003; 78(4):873S-880S. DOI: 10.1093/ajcn/78.4.873S. View

16.

Malik V, Schulze M, Hu F . Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr. 2006; 84(2):274-88. PMC: 3210834. DOI: 10.1093/ajcn/84.1.274. View

17.

Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M . Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol. 2009; 170(5):537-45. PMC: 2732984. DOI: 10.1093/aje/kwp145. View

18.

Martinez-Cortes G, Salazar-Flores J, Haro-Guerrero J, Rubi-Castellanos R, Velarde-Felix J, Munoz-Valle J . Maternal admixture and population structure in Mexican-Mestizos based on mtDNA haplogroups. Am J Phys Anthropol. 2013; 151(4):526-37. DOI: 10.1002/ajpa.22293. View

19.

Holla L, Borilova Linhartova P, Lucanova S, Kastovsky J, Musilova K, Bartosova M . GLUT2 and TAS1R2 Polymorphisms and Susceptibility to Dental Caries. Caries Res. 2015; 49(4):417-24. DOI: 10.1159/000430958. View

20.

Baum C, Brown M . Low-fat, high-carbohydrate diets and atherogenic risk. Nutr Rev. 2000; 58(5):148-51. DOI: 10.1111/j.1753-4887.2000.tb01850.x. View