New Perspectives on the Hepatitis B Virus Life Cycle in the Human Liver

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2016 Feb 23

PMID 26901815

Citations 13

Authors

Peter A Revill

Stephen A Locarnini

Affiliations

Soon will be listed here.

Abstract

The central role of the transcriptional template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to study in patients with chronic hepatitis B (CHB) infection. In this issue of the JCI, Zhang and colleagues reveal a mosaic distribution of viral antigens and nucleic acids and a mismatch between HBV cccDNA, RNA, and expression of the hepatitis B surface antigen (HBsAg). These unusual patterns varied over the natural history of CHB, prompting the authors to propose a new three-stage model of the HBV life cycle at the single-cell level.

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