Polyurethane/poly(vinyl Alcohol) Hydrogel Coating Improves the Cytocompatibility of Neural Electrodes

Overview

Journal Neural Regen Res

Date 2016 Feb 19

PMID 26889197

Citations 2

Authors

Mei Li

Hai-Han Zhou

Tao Li

Cheng-Yan Li

Zhong-Yuan Xia

Yanwen Y Duan

Affiliations

Soon will be listed here.

Abstract

Neural electrodes, the core component of neural prostheses, are usually encapsulated in polydimethylsiloxane (PDMS). However, PDMS can generate a tissue response after implantation. Based on the physicochemical properties and excellent biocompatibility of polyurethane (PU) and poly(vinyl alcohol) (PVA) when used as coating materials, we synthesized PU/PVA hydrogel coatings and coated the surface of PDMS using plasma treatment, and the cytocompatibility to rat pheochromocytoma (PC12) cells was assessed. Protein adsorption tests indicated that the amount of protein adsorption onto the PDMS substrate was reduced by 92% after coating with the hydrogel. Moreover, the PC12 cells on the PU/PVA-coated PDMS showed higher cell density and longer and more numerous neurites than those on the uncoated PDMS. These results indicate that the PU/PVA hydrogel is cytocompatible and a promising coating material for neural electrodes to improve their biocompatibility.

Citing Articles

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes.

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PMID: 31333407 PMC: 6624471. DOI: 10.3389/fnins.2019.00689.

A Materials Roadmap to Functional Neural Interface Design.

Wellman S, Eles J, Ludwig K, Seymour J, Michelson N, McFadden W Adv Funct Mater. 2018; 28(12).

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