Association Study of BUD13-ZNF259 Gene Rs964184 Polymorphism and Hemorrhagic Stroke Risk

Overview

Journal Int J Clin Exp Med

Specialty General Medicine

Date 2016 Feb 18

PMID 26885234

Citations 5

Authors

Shengjun Zhou

Jikuang Zhao

Zhepei Wang

Keqin Li

Sheng Nie

Feng Gao

Jie Sun

Xiang Gao

Yi Huang

Affiliations

Soon will be listed here.

Abstract

We aimed to evaluate the association of rs964184 of BUD13-ZNF259 gene with the risk of hemorrhagic stroke (HS). A total of 138 HS cases and 587 controls were recruited for the association of rs964184 of BUD13-ZNF259 gene with the risk of HS. Tm shift PCR was used for genotyping. We were unable to find the association of rs964184 of BUD13-ZNF259 gene with the risk of HS (P>0.05). Significant difference was found in the TG level among the three genotypes (CC: 1.51±1.02; CG: 1.68±1.10; GG: 1.90±1.11, P=0.036). The TG level showed strong correlation with rs964184 genotypes (P=0.010, correlation=0.101). Significantly higher TC, HDL-C, and LDL-C levels were observed in the case group. And no difference was found in the TG, ApoA-I, ApoB. Our case-control study supported the significant association between rs964184 genotype and the blood TG concentration, although we were unable to find association between BUD13-ZNF259 rs964184 and the risk of HS in Han Chinese.

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References

Yi X, Lin J, Wang C, Zhang B, Chi W . A comparative study of dual versus monoantiplatelet therapy in patients with acute large-artery atherosclerosis stroke. J Stroke Cerebrovasc Dis. 2014; 23(7):1975-81. DOI: 10.1016/j.jstrokecerebrovasdis.2014.01.022. View

Zhou J, Huang Y, Huang R, Wang F, Xu L, Le Y . A case-control study provides evidence of association for a common SNP rs974819 in PDGFD to coronary heart disease and suggests a sex-dependent effect. Thromb Res. 2012; 130(4):602-6. DOI: 10.1016/j.thromres.2012.05.023. View

Zhang X, Qi Q, Bray G, Hu F, Sacks F, Qi L . APOA5 genotype modulates 2-y changes in lipid profile in response to weight-loss diet intervention: the Pounds Lost Trial. Am J Clin Nutr. 2012; 96(4):917-22. PMC: 3441115. DOI: 10.3945/ajcn.112.040907. View

Reutov V, Sorokina E, Shvalev V, Kosmachevskaia O, Krushinskii A, Kuzenkov V . [The possible role of nitrogen dioxide produced in the field of bifurcation of vessels, in the processes of their damage in hemorrhagic strokes, and the formation of atherosclerotic plaques]. Usp Fiziol Nauk. 2012; 43(4):73-93. View

Isley W . Low-density lipoprotein cholesterol lowering in the prevention of CHD: how low should we go?. Curr Treat Options Cardiovasc Med. 2006; 8(4):289-97. DOI: 10.1007/s11936-006-0050-6. View

Tsai C, Thomas B, Sudlow C . Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review. Neurology. 2013; 81(3):264-72. PMC: 3770160. DOI: 10.1212/WNL.0b013e31829bfde3. View

Brautbar A, Covarrubias D, Belmont J, Lara-Garduno F, Virani S, Jones P . Variants in the APOA5 gene region and the response to combination therapy with statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia. Atherosclerosis. 2011; 219(2):737-42. PMC: 6174528. DOI: 10.1016/j.atherosclerosis.2011.08.015. View

Yates P, Villemagne V, Ellis K, Desmond P, Masters C, Rowe C . Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front Neurol. 2014; 4:205. PMC: 3881231. DOI: 10.3389/fneur.2013.00205. View

Huang Y, Lian J, Huang R, Wang F, Xu L, Le Y . Positive association between rs10918859 of the NOS1AP gene and coronary heart disease in male Han Chinese. Genet Test Mol Biomarkers. 2012; 17(1):25-9. PMC: 3903165. DOI: 10.1089/gtmb.2012.0254. View

10.

Wang J, Chuang K, Ahluwalia M, Patel S, Umblas N, Mirel D . High-throughput SNP genotyping by single-tube PCR with Tm-shift primers. Biotechniques. 2005; 39(6):885-93. DOI: 10.2144/000112028. View

11.

Zhang L, Sun Y, Liang Y, Li K, Chen Y, Gusanglamu . Relationship between dyslipidemia and gene polymorphism in Tibetan population. Biomed Environ Sci. 2012; 25(3):305-10. DOI: 10.3967/0895-3988.2012.03.008. View

12.

Waterworth D, Ricketts S, Song K, Chen L, Zhao J, Ripatti S . Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol. 2010; 30(11):2264-76. PMC: 3891568. DOI: 10.1161/ATVBAHA.109.201020. View

13.

Sturgeon J, Folsom A, Longstreth Jr W, Shahar E, Rosamond W, Cushman M . Risk factors for intracerebral hemorrhage in a pooled prospective study. Stroke. 2007; 38(10):2718-25. DOI: 10.1161/STROKEAHA.107.487090. View

14.

Wang Q, Ding H, Tang J, Zhang L, Xu Y, Yan J . C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population. Acta Pharmacol Sin. 2009; 30(3):291-8. PMC: 4002404. DOI: 10.1038/aps.2009.14. View

15.

Woo D, Deka R, Falcone G, Flaherty M, Haverbusch M, Martini S . Apolipoprotein E, statins, and risk of intracerebral hemorrhage. Stroke. 2013; 44(11):3013-7. PMC: 3873717. DOI: 10.1161/STROKEAHA.113.001304. View

16.

Gu B, Zhao Y, Yang Z, Li H, Yu F . HindIII polymorphism in the lipoprotein lipase gene and hypertensive intracerebral hemorrhage in the Chinese Han population. J Stroke Cerebrovasc Dis. 2014; 23(6):1275-81. DOI: 10.1016/j.jstrokecerebrovasdis.2013.10.024. View

17.

Lopez-Mejias R, Genre F, Garcia-Bermudez M, Castaneda S, Gonzalez-Juanatey C, Llorca J . The 11q23.3 genomic region-rs964184-is associated with cardiovascular disease in patients with rheumatoid arthritis. Tissue Antigens. 2013; 82(5):344-7. DOI: 10.1111/tan.12217. View

18.

Zahuranec D, Lisabeth L, Sanchez B, Smith M, Brown D, Garcia N . Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology. 2014; 82(24):2180-6. PMC: 4113463. DOI: 10.1212/WNL.0000000000000519. View

19.

Liao F, Hori Y, Hudry E, Bauer A, Jiang H, Mahan T . Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. J Neurosci. 2014; 34(21):7281-92. PMC: 4028501. DOI: 10.1523/JNEUROSCI.0646-14.2014. View

20.

Braun T, Been L, Singhal A, Worsham J, Ralhan S, Wander G . A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. PLoS One. 2012; 7(5):e37056. PMC: 3356398. DOI: 10.1371/journal.pone.0037056. View