More Than Osteoporosis: Age-specific Issues in Bone Health

Overview

Journal Curr Opin HIV AIDS

Specialty Infectious Diseases

Date 2016 Feb 17

PMID 26882460

Citations 8

Authors

Kristine M Erlandson

Giovanni Guaraldi

Julian Falutz

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The interaction between fall and fracture risk factors is an area of increasing clinical relevance, but little information is known about the age-specific issues in bone health unique to HIV-infected adults. The present review will focus on what is known about falls and fall risk factors among HIV-infected adults, and then review the association between decreased muscle, increased adiposity, and frailty with both low bone mineral density (BMD) and falls.

Recent Findings: The rate of falls among middle-aged HIV-infected adults is similar to that of HIV-uninfected adults 65 years and older. Many of the clinical factors that contribute to low BMD overlap with risk factors for falls, resulting in a high risk of a serious fall among older adults with the greatest risk for a fracture. Low muscle mass, increased adiposity and metabolic syndrome, physical function impairment and frailty, common among older HIV-infected adults, contribute to an increased risk for low BMD and falls, and subsequently, may increase the risk of fracture among HIV-infected older adults.

Summary: Interventions with dual benefit on reducing fall risk and improving BMD are likely to have the greatest impact on fracture prevention in the older, HIV-infected adult.

Citing Articles

Older HIV-infected adults: complex patients- geriatric syndromes (II).

Bertagnoli L, Iannuzzi P, Ciccone S, Canevelli M, Marzetti E, Guaraldi G Eur Geriatr Med. 2021; 10(2):213-218.

PMID: 34652755 DOI: 10.1007/s41999-019-00160-w.

Short Communication: Low Muscle Mass Is Associated with Osteoporosis in Older Adults Living with HIV.

Oursler K, Iranmanesh A, Jain C, Birkett K, Briggs B, Garner D AIDS Res Hum Retroviruses. 2019; 36(4):300-302.

PMID: 31762303 PMC: 7185343. DOI: 10.1089/AID.2019.0207.

Fall History and Associated Factors Among Adults Living With HIV-1 in the Cape Winelands, South Africa: An Exploratory Investigation.

Berner K, Strijdom H, Essop M, Webster I, Morris L, Louw Q Open Forum Infect Dis. 2019; 6(10):ofz401.

PMID: 31660363 PMC: 6785680. DOI: 10.1093/ofid/ofz401.

Chronic Distal Sensory Polyneuropathy Is a Major Contributor to Balance Disturbances in Persons Living With HIV.

Sakabumi D, Moore R, Tang B, Delaney P, Keltner J, Ellis R J Acquir Immune Defic Syndr. 2019; 80(5):568-573.

PMID: 30649035 PMC: 6482029. DOI: 10.1097/QAI.0000000000001953.

Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men.

Erlandson K, Lake J, Sim M, Falutz J, Prado C, Domingues da Silva A J Acquir Immune Defic Syndr. 2017; 77(3):288-294.

PMID: 29140875 PMC: 5807215. DOI: 10.1097/QAI.0000000000001591.

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