Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Overview

Journal Biochem Res Int

Publisher Wiley

Specialty Biochemistry

Date 2016 Feb 17

PMID 26881078

Citations 11

Authors

Volodymyr Gryshchuk

Natalya Galagan

Affiliations

Soon will be listed here.

Abstract

Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The aim of present work was studying of the primary effects of silica nanoparticles (SiNPs) on haemostasis in vitro. We studied the effect of SiNPs on blood coagulation directly estimating the activation of prothrombin and factor X and to verify any possible effect of SiNPs on human platelets. It was shown that SiNPs shortened coagulation time in APTT and PT tests and increased the activation of factor X induced by RVV possibly due to the sorption of intrinsic pathway factors on their surface. SiNPs inhibited the aggregation of platelet rich plasma induced by ADP but in the same time partially activated platelets as it was shown using flow cytometry. The possibility of SiNPs usage in nanomedicine is strongly dependant on their final concentration in bloodstream and the size of the particles that are used. However SiNPs are extremely promising as the haemostatic agents for preventing the blood loss after damage.

Citing Articles

Immunological properties of silica nanoparticles: a structure-activity relationship study.

Grunberger J, Dobrovolskaia M, Ghandehari H Nanotoxicology. 2024; 18(6):542-564.

PMID: 39282894 PMC: 11581911. DOI: 10.1080/17435390.2024.2401448.

Effect of silica-sprayed collection tubes on synovial fluid bacterial culture.

Jimenez Rihuete P, Martin C, Villarino N, Rubio-Martinez L Vet Med Sci. 2024; 10(4):e1501.

PMID: 38923315 PMC: 11196375. DOI: 10.1002/vms3.1501.

Application of non-metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011-2021.

Zadeh Mehrizi T, Shafiee Ardestani M Prog Biomater. 2022; 11(2):137-161.

PMID: 35536502 PMC: 9085557. DOI: 10.1007/s40204-022-00188-5.

A novel murine in vivo model for acute hereditary angioedema attacks.

Bupp S, Whittaker M, Lehtimaki M, Park J, Dement-Brown J, Zhou Z Sci Rep. 2021; 11(1):15924.

PMID: 34354123 PMC: 8342443. DOI: 10.1038/s41598-021-95125-0.

Nanoparticle-Based Technology Approaches to the Management of Neurological Disorders.

Sim T, Tarini D, Dheen S, Bay B, Srinivasan D Int J Mol Sci. 2020; 21(17).

PMID: 32842530 PMC: 7503838. DOI: 10.3390/ijms21176070.

References

Ilinskaya A, Dobrovolskaia M . Nanoparticles and the blood coagulation system. Part II: safety concerns. Nanomedicine (Lond). 2013; 8(6):969-81. PMC: 3939602. DOI: 10.2217/nnm.13.49. View

Konokhova A, Yurkin M, Moskalensky A, Chernyshev A, Tsvetovskaya G, Chikova E . Light-scattering flow cytometry for identification and characterization of blood microparticles. J Biomed Opt. 2012; 17(5):057006. DOI: 10.1117/1.JBO.17.5.057006. View

Hao N, Li L, Tang F . Shape-mediated biological effects of mesoporous silica nanoparticles. J Biomed Nanotechnol. 2015; 10(10):2508-38. DOI: 10.1166/jbn.2014.1940. View

Marsh N, Williams V . Practical applications of snake venom toxins in haemostasis. Toxicon. 2005; 45(8):1171-81. DOI: 10.1016/j.toxicon.2005.02.016. View

Sambasivan C, Cho S, Zink K, Differding J, Schreiber M . A highly porous silica and chitosan-based hemostatic dressing is superior in controlling hemorrhage in a severe groin injury model in swine. Am J Surg. 2009; 197(5):576-80. DOI: 10.1016/j.amjsurg.2008.12.011. View

Cattaneo M, Cerletti C, Harrison P, Hayward C, Kenny D, Nugent D . Recommendations for the Standardization of Light Transmission Aggregometry: A Consensus of the Working Party from the Platelet Physiology Subcommittee of SSC/ISTH. J Thromb Haemost. 2013; . DOI: 10.1111/jth.12231. View

Castro H, Zingali R, Albuquerque M, Pujol-Luz M, Rodrigues C . Snake venom thrombin-like enzymes: from reptilase to now. Cell Mol Life Sci. 2004; 61(7-8):843-56. PMC: 11138602. DOI: 10.1007/s00018-003-3325-z. View

Kushida T, Saha K, Subramani C, Nandwana V, Rotello V . Effect of nano-scale curvature on the intrinsic blood coagulation system. Nanoscale. 2014; 6(23):14484-7. PMC: 4224616. DOI: 10.1039/c4nr04128c. View

Corbalan J, Medina C, Jacoby A, Malinski T, Radomski M . Amorphous silica nanoparticles aggregate human platelets: potential implications for vascular homeostasis. Int J Nanomedicine. 2012; 7:631-9. PMC: 3278227. DOI: 10.2147/IJN.S28293. View

10.

Zhang P, Kong J . Doxorubicin-tethered fluorescent silica nanoparticles for pH-responsive anticancer drug delivery. Talanta. 2015; 134:501-507. DOI: 10.1016/j.talanta.2014.09.041. View

11.

Jamil B, Bokhari H, Imran M . Mechanism of Action: How Nano-Antimicrobials Act?. Curr Drug Targets. 2015; 18(3):363-373. DOI: 10.2174/1389450116666151019101826. View

12.

Park K . Controlled drug delivery systems: past forward and future back. J Control Release. 2014; 190:3-8. PMC: 4142099. DOI: 10.1016/j.jconrel.2014.03.054. View

13.

Englehart M, Cho S, Tieu B, Morris M, Underwood S, Karahan A . A novel highly porous silica and chitosan-based hemostatic dressing is superior to HemCon and gauze sponges. J Trauma. 2008; 65(4):884-90. DOI: 10.1097/TA.0b013e318187800b. View

14.

Liu X, Sun J . Time-course effects of intravenously administrated silica nanoparticles on blood coagulation and endothelial function in rats. J Nanosci Nanotechnol. 2013; 13(1):222-8. DOI: 10.1166/jnn.2013.6910. View

15.

Lee S, Kim M, Lee D, Kwon T, Khang D, Yun H . The comparative immunotoxicity of mesoporous silica nanoparticles and colloidal silica nanoparticles in mice. Int J Nanomedicine. 2013; 8:147-58. PMC: 3544348. DOI: 10.2147/IJN.S39534. View

16.

Lord M, Cousins B, Doherty P, Whitelock J, Simmons A, Williams R . The effect of silica nanoparticulate coatings on serum protein adsorption and cellular response. Biomaterials. 2006; 27(28):4856-62. DOI: 10.1016/j.biomaterials.2006.05.037. View

17.

Andreani T, Kiill C, de Souza A, Fangueiro J, Fernandes L, Doktorovova S . Surface engineering of silica nanoparticles for oral insulin delivery: characterization and cell toxicity studies. Colloids Surf B Biointerfaces. 2014; 123:916-23. DOI: 10.1016/j.colsurfb.2014.10.047. View

18.

Lu J, Liong M, Zink J, Tamanoi F . Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small. 2007; 3(8):1341-6. DOI: 10.1002/smll.200700005. View

19.

Jackson S . The growing complexity of platelet aggregation. Blood. 2007; 109(12):5087-95. DOI: 10.1182/blood-2006-12-027698. View

20.

Lin X, Zhao N, Yan P, Hu H, Xu F . The shape and size effects of polycation functionalized silica nanoparticles on gene transfection. Acta Biomater. 2014; 11:381-92. DOI: 10.1016/j.actbio.2014.09.004. View