MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2016 Feb 17

PMID 26880947

Citations 6

Authors

Giuseppina Catanzaro

Zein Mersini Besharat

Neha Garg

Maurizio Ronci

Luisa Pieroni

Evelina Miele

Angela Mastronuzzi

Andrea Carai

Vincenzo Alfano

Agnese Po

Isabella Screpanti

Franco Locatelli

Andrea Urbani

Elisabetta Ferretti

Affiliations

Soon will be listed here.

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers. Among them, stem-like cells (hMB-SLCs) represent a fraction of the tumor cell population with the potential of self-renewal and proliferation and have been associated with tumor poor prognosis. In this context, microRNAs have been described as playing a pivotal role in stem cells differentiation. In our paper, we analyze microRNAs profile and genes expression of hMB-SLCs before and after Retinoic Acid- (RA-) induced differentiation. We aimed to identify pivotal players of specific pathways sustaining stemness and/or tumor development and progression and integrate the results of our recent proteomic study. Our results uncovered 22 differentially expressed microRNAs that were used as input together with deregulated genes and proteins in the Genomatix Pathway System (GePS) analysis revealing 3 subnetworks that could be interestingly involved in the maintenance of hMB-SLCs proliferation. Taken together, our findings highlight microRNAs, genes, and proteins that are significantly modulated in hMB-SLCs with respect to their RA-differentiated counterparts and could open new perspectives for prognostic and therapeutic intervention on MB.

Citing Articles

The Non-coding Side of Medulloblastoma.

Laneve P, Caffarelli E Front Cell Dev Biol. 2020; 8:275.

PMID: 32528946 PMC: 7266940. DOI: 10.3389/fcell.2020.00275.

Sonic Hedgehog Medulloblastoma Cancer Stem Cells Mirnome and Transcriptome Highlight Novel Functional Networks.

Po A, Abballe L, Sabato C, Gianno F, Chiacchiarini M, Catanzaro G Int J Mol Sci. 2018; 19(8).

PMID: 30096798 PMC: 6121264. DOI: 10.3390/ijms19082326.

Circulating MicroRNAs in Elderly Type 2 Diabetic Patients.

Catanzaro G, Besharat Z, Chiacchiarini M, Abballe L, Sabato C, Vacca A Int J Endocrinol. 2018; 2018:6872635.

PMID: 29849622 PMC: 5914089. DOI: 10.1155/2018/6872635.

Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs.

Bisicchia E, Sasso V, Catanzaro G, Leuti A, Besharat Z, Chiacchiarini M Mol Neurobiol. 2018; 55(8):6894-6905.

PMID: 29357041 DOI: 10.1007/s12035-018-0889-z.

Loss of miR-107, miR-181c and miR-29a-3p Promote Activation of Notch2 Signaling in Pediatric High-Grade Gliomas (pHGGs).

Catanzaro G, Sabato C, Russo M, Rosa A, Abballe L, Besharat Z Int J Mol Sci. 2017; 18(12).

PMID: 29258209 PMC: 5751342. DOI: 10.3390/ijms18122742.

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