Membranous Glomerulonephritis in a Patient with Myelodysplastic Syndrome-refractory Cytopenia with Multilineage Dysplasia

Overview

Journal Kidney Res Clin Pract

Specialty Nephrology

Date 2016 Feb 16

PMID 26877929

Citations 3

Authors

Kwang Il Ko

Mi Jung Lee

Fa Mee Doh

Hyang Mo Koo

Chan Ho Kim

Dong Ho Shin

Hyung Jung Oh

Seung Hyeok Han

Shin-Wook Kang

Kyu Hun Choi

Tae-Hyun Yoo

Affiliations

Soon will be listed here.

Abstract

A 74-year-old woman presented with edema in the lower extremities. Laboratory tests revealed anemia, thrombocytopenia, hypoalbuminemia, hypercholesterolemia, and nephrotic-range proteinuria. Myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) was confirmed by bone marrow biopsy. Renal biopsy demonstrated membranous glomerulonephritis (MGN), stage I. Based on these clinicopathologic results, she was diagnosed as having MGN with MDS-RCMD. This is a rare case report of MGN in a parient with MDS-RCMD featuring nephrotic syndrome.

Citing Articles

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Lafargue M, Duong van Huyen J, Rennke H, Essig M, Bobot M, Jourde-Chiche N Clin Kidney J. 2024; 17(8):sfae185.

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Spectrum of Kidney Involvement in Patients with Myelodysplastic Syndromes.

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References

Bogdanovic R, Kuzmanovic M, Markovic-Lipkovski J, Ognjanovic M, Micic D, Stankovic I . Glomerular involvement in myelodysplastic syndromes. Pediatr Nephrol. 2002; 16(12):1053-7. DOI: 10.1007/s004670100025. View

Vardiman J, Lee Harris N, Brunning R . The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002; 100(7):2292-302. DOI: 10.1182/blood-2002-04-1199. View

Nishida M, Ishida H, Nakai N, Morimoto A, Imashuku S, Hamaoka K . Focal segmental glomerulosclerosis in a girl with myelodysplastic syndrome. Nephrol Dial Transplant. 2004; 19(10):2639-41. DOI: 10.1093/ndt/gfh345. View

Verhoef G, De Schouwer P, Ceuppens J, Van Damme J, Goossens W, Boogaerts M . Measurement of serum cytokine levels in patients with myelodysplastic syndromes. Leukemia. 1992; 6(12):1268-72. View

Enright H, JACOB H, Vercellotti G, Howe R, Belzer M, Miller W . Paraneoplastic autoimmune phenomena in patients with myelodysplastic syndromes: response to immunosuppressive therapy. Br J Haematol. 1995; 91(2):403-8. DOI: 10.1111/j.1365-2141.1995.tb05310.x. View

Saitoh T, Murakami H, Uchiumi H, Moridaira K, Maehara T, Matsushima T . Myelodysplastic syndromes with nephrotic syndrome. Am J Hematol. 1999; 60(3):200-4. DOI: 10.1002/(sici)1096-8652(199903)60:3<200::aid-ajh6>3.0.co;2-0. View

Lefaucheur C, Stengel B, Nochy D, Martel P, Hill G, Jacquot C . Membranous nephropathy and cancer: Epidemiologic evidence and determinants of high-risk cancer association. Kidney Int. 2006; 70(8):1510-7. DOI: 10.1038/sj.ki.5001790. View

Morschhauser F, Wattel E, Pagniez D, Lovi V, Rose C, Bauters F . Glomerular injury in chronic myelomonocytic leukemia. Leuk Lymphoma. 1995; 18(5-6):479-83. DOI: 10.3109/10428199509059648. View

Moulin B, Ronco P, Mougenot B, Francois A, Fillastre J, Mignon F . Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas. Kidney Int. 1992; 42(1):127-35. DOI: 10.1038/ki.1992.270. View

10.

Paydas S, Tuncer I, Zorludemir S, Gonlusen G . A case with membranous glomerulonephritis and myelodysplastic syndrome. Nephron. 1992; 62(2):231-2. DOI: 10.1159/000187040. View

11.

Apostolou T, Sotsiou F, Pappas C, Rontoianni D, Apostolidis J, Nikolopoulou N . Atheroembolic renal disease and membranous nephropathy, in a patient with myelodysplastic syndrome, eosinophilia, and trisomy 8. Nephrol Dial Transplant. 2002; 17(7):1336-8. DOI: 10.1093/ndt/17.7.1336. View

12.

Magil A, Cohen A . Monocytes and focal glomerulosclerosis. Lab Invest. 1989; 61(4):404-9. View

13.

Kouides P, Bennett J . Morphology and classification of the myelodysplastic syndromes and their pathologic variants. Semin Hematol. 1996; 33(2):95-110. View

14.

Bynoe A, Scott C, Ford P, Roberts B . Decreased T helper cells in the myelodysplastic syndromes. Br J Haematol. 1983; 54(1):97-102. DOI: 10.1111/j.1365-2141.1983.tb02071.x. View

15.

Shapiro C, Vander Laan B, Jao W, Sloan D . Nephrotic syndrome in two patients with cured Hodgkin's disease. Cancer. 1985; 55(8):1799-804. DOI: 10.1002/1097-0142(19850415)55:8<1799::aid-cncr2820550827>3.0.co;2-s. View